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Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates
Wang B. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates
ผู้แต่ง / หัวหน้าโครงการ (EN): Wang B.
บทคัดย่อ (EN): The variable number of tandem repeats (VNTRs) provides valuable information about both the functional and evolutionary aspects of genetic diversity. Comparative analysis of 3 Plasmodium falciparum genomes has shown that more than 9% of its open reading frames (ORFs) harbor VNTRs. Although microsatellites and VNTR genes of P. vivax were reported, the VNTR polymorphism of genes has not been examined widely. In this study, 230 P. vivax genes were analyzed for VNTRs by SERV, and 33 kinds of TR deletions or insertions from 29 P. vivax genes (12.6%) were found. Of these, 9 VNTR fragments from 8 P. vivax genes were used for PCR amplification and sequence analysis to examine the genetic diversity among 134 isolates from four Southeast Asian countries (China, Republic of Korea, Thailand, and Myanmar) with different malaria endemicity. We confirmed the existence of extensive polymorphism of VNTR fragments in field isolates. This detection provides several suitable markers for analysis of the molecular epidemiology of P. vivax field isolates. © 2017 Elsevier B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85014868895&doi=10.1016%2fj.actatropica.2017.01.013&partnerID=40&md5=32052a27e5868876848bafaacc5053df
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Polymorphism, Genetic
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates
Wang B.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Insights into the naturally acquired immune response to Plasmodium vivax malaria Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border Natural Plasmodium vivax infections in Anopheles mosquitoes in a malaria endemic area of northeastern Thailand Association of IL1B –31C/T and IL1RA Variable Number of an 86-bp Tandem Repeat With Dengue Shock Syndrome in Thailand Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10 Re-assessing the relationship between sporozoite dose and incubation period in Plasmodium vivax malaria: A systematic re-analysis Genetic analysis of Thai cattle reveals a Southeast Asian indicine ancestry A randomized, double-blind, active-control trial to evaluate the efficacy and safety of a three day course of tafenoquine monotherapy for the treatment of Plasmodium vivax malaria
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