คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Patamaporn Pruksakorn

เผยแพร่โดย

1 Medical Life Sciences Institute, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand 2 National Institute of Health, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand 3 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand

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งานวิจัยที่แนะนำ Erratum to: Micro-morphological study of Evolvulus spp. (Convolvulaceae): the old world medicinal plants (Bot Stud, (2016), 57, (25), 10.1186/s40529-016-0141-y) Downregulation of transcription factor LRF/ZBTB7A increases fetal hemoglobin expression in -thalassemia/hemoglobin E erythroid cells RUBBER- BASED AGROFORESTRY IN FIVE STATES: EFFORT TOWARDS CONSERVING FARMERS’ PRIOTIZED MEDICINAL PLANTS IN NIGERIA. UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells Investigation of FoxO3 dynamics during erythroblast development in β-thalassemia major Histone modification levels in β-thalassemia/hemoglobin E erythroid cells Medicinal and surgical management of tail infections in buffaloes (Buffalo Bulletin,39(1)) Decreased nitrite reductase activity of deoxyhemoglobin correlates with platelet activation in hemoglobin E/ß-thalassemia subjects ZNF802 (JAZF1), a possible new therapeutic target for treatment of beta-thalassemia Micro-morphological study of Evolvulus spp. (Convolvulaceae): the old world medicinal plants

คัดลอก URL

ชื่อเรื่อง (EN):	Development of fetal hemoglobin inducers from medicinal plants for the clinical management of beta-thalassemia
ผู้แต่ง / หัวหน้าโครงการ (EN):	Patamaporn Pruksakorn
บทคัดย่อ (EN):	Thalassemia is the most common genetic disorder in Thailand. Beta-thalassemia is caused by reduced or absent of ß-globin resulting in insufficient adult hemoglobin (HbA, a2ß2) production. One of the most effective strategies to reduce severe anemia in patients is an increasing level of fetal hemoglobin (HbF, a2g2) to compensate the lack of HbA. This study, we aimed to develop a cell-based assay system for searching the active substances inducing g-globin and HbF expression. The cell model was designed and established for the detection of HBG (g-globin gene) promoter-activating activity associated with g-globin expression. This system was used to test over 180 extracts from medicinal plants. Of these, 7 plants extracts exhibited the high HBG promoter-activating activity. Five active substances, belong to flavonoid and benzofuranone classes, were able to isolate from these plant extracts. The substances were investigated for g-globin mRNA and HbF levels by quantitative PCR and HPLC-PDA analysis, respectively. The active substance T01 elevated g-globin expression and increased HbF level to 1.7-2.8 folds in K564 cell line. Moreover, F-cell induction was revealed in beta-thalassemia derived erythroid progenitor cells treated with T01, suggesting that T01 would be a promising HbF inducer to use as medical aids for beta-thalassemia patients.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=698
เผยแพร่โดย (EN):	1 Medical Life Sciences Institute, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand 2 National Institute of Health, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand 3 Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
คำสำคัญ (EN):	Medicinal plants
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science