สืบค้นงานวิจัย
Association between subclinical malaria infection and inflammatory host response in a pre-elimination setting
Peto T.J. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Association between subclinical malaria infection and inflammatory host response in a pre-elimination setting
ผู้แต่ง / หัวหน้าโครงการ (EN): Peto T.J.
บทคัดย่อ (EN): Subclinical infections in endemic areas of Southeast Asia sustain malaria transmission. These asymptomatic infections might sustain immunity against clinical malaria and have been considered benign for the host, but if they are associated with chronic low-grade inflammation this could be harmful. We conducted a case-control study to explore the association between subclinical malaria and C-reactive protein (CRP), an established biomarker of inflammation. Methods: Blood samples from asymptomatic villagers in Pailin, Western Cambodia were tested for malaria by high-volume ultra-sensitive polymerase chain reaction (uPCR) to determine the Plasmodium species. Plasma CRP concentration was measured in 328 individuals with parasitaemia (cases) and compared with: i) the same individual's value at the first time point when they had no detectable parasites (n = 282); and ii) age- sex- and village-matched controls (n = 328) free of Plasmodium infection. Plasma CRP concentrations were compared against thresholds of 3mg/L and 10mg/L. Subgroup analysis was carried out for cases with P vivax and P falciparum mono-infections. Results: Median plasma CRP level for all samples was 0.59mg/L (interquartile range: 0.24-1.64mg/ L). CRP concentrations were higher in parasitaemic individuals compared with same-person-controls (p = 0.050); and matched-controls (p = 0.025). 4.9% of samples had CRP concentrations above 10mg/L and 14.6% were above 3mg/L. Cases were more likely to have plasma CRP concentrations above these thresholds than age/sex matched controls, odds ratio 3.5 (95%CI 1.5-9.8) and 1.8 (95%CI 1.1-2.9), respectively. Amongst cases, parasite density and CRP were positively correlated (p<0.001), an association that remained significant when controlling for age and fever. Individuals with P.vivax mono-infections had the highest plasma CRP concentrations with the greatest association with parasitaemia. Discussion: In this setting persistent malaria infections in asymptomatic individuals were associated with moderately elevated plasma CRP concentrations; chiefly evident in cases with P.vivax mono-infections. As well as interrupting malaria transmission within the community, treatment of asymptomatic malaria infections, in particular radical cure of vivax malaria, may benefit the health of infected individuals. © 2016 Peto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84978647643&doi=10.1371%2fjournal.pone.0158656&partnerID=40&md5=1e286c9e909c1cae605ce27c6a1081bc
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Polymerase Chain Reaction
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Peto T.J.. "Association between subclinical malaria infection and inflammatory host response in a pre-elimination setting". ไม่ระบุหน่วยงาน. ม.ป.ป.

Peto T.J.. "Association between subclinical malaria infection and inflammatory host response in a pre-elimination setting". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Association between subclinical malaria infection and inflammatory host response in a pre-elimination setting
Peto T.J.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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