คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Pinyaphat Khamphikham

เผยแพร่โดย

1 Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand 2 Department of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand 3 Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 4 Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 5 Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA 6 Department of Medical Sciences, National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand

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หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ In vitro generation of dendritic cell - breast cancer cell hybrids for induction of cellular immunity ความผิดปกติทางเพศของหอยทะเลฝาเดียวที่เกิดจากสารป้องกันการเกาะติดของสิ่งมีชีวิตในบริเวณชายฝั่งทะเลตะวันออกของอ่าวไทย ระยะที่ 3: การเหนี่ยวนำให้เกิดความผิดปกติทางเพศ (Imposex induction) ในห้องปฏิบัติการ Real time monitoring cell proliferation of SW620 colorectal cancer cell line following co-culture with PHA-stimulated lymphocytes and CD44 expression following cytotoxic and apoptotic induction การคัดเลือกสายพันธุ์หนูไมซ์ต้นแบบเพื่อศึกษาการเจริญเติบโตของมะเร็งเต้านม จากการเหนี่ยวนำด้วยเซลล์เพาะเลี้ยง MDA-MB-231 Mice model for tumor growth with MDA-MB-231 cell line induction study UNC0638 induces high levels of fetal hemoglobin expression in β-thalassemia/HbE erythroid progenitor cells Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS Downregulation of transcription factor LRF/ZBTB7A increases fetal hemoglobin expression in -thalassemia/hemoglobin E erythroid cells SHORT CUTS ON BASAL AND HIGH LEVEL VIRGIN BARK Histone modification levels in β-thalassemia/hemoglobin E erythroid cells

คัดลอก URL

ชื่อเรื่อง (EN):	High-level induction of fetal haemoglobin by pomalidomide in β-thalassaemia/HbE erythroid progenitor cells
ผู้แต่ง / หัวหน้าโครงการ (EN):	Pinyaphat Khamphikham
บทคัดย่อ (EN):	Increased expression of fetal haemoglobin (HbF; α2γ2) can ameliorate red blood cell deficiencies in patients with β‐thalassaemia and sickle cell disease (SCD). Pharmacological induction of HbF expression in β‐thalassaemia has been investigated using several classes of small molecules, including 5‐azacytidine, decitabine, hydroxyurea, LSD1 inhibitors (tranylcypromine and RN‐1), and short chain fatty acid derivatives. Pomalidomide, an FDA‐approved immunomodulatory drug for the treatment of multiple myeloma, stimulates γ‐globin mRNA and HbF expression in erythroid progenitor cells by downregulating factors involved in γ‐globin repression, including BCL11A, SOX6, GATA1, KLF1 and LSD1. The present data show that pomalidomide significantly increased γ‐globin mRNA expression, achieving a 2.3±0.3-fold increase over control cells, with coincidentally diminished β‐globin expression, without significant change in α‐globin expression. The differentiation of β0‐thalassaemia/HbE progenitor cells significantly improved after treatment with either decitabine alone or pomalidomide plus decitabine. These results suggest that pomalidomide is a potent HbF inducer and is more potent than hydroxyurea. The combination of pomalidomide and decitabine provide additive effects in inducing HbF expression in erythroid cells from β0‐thalassaemia/HbE patients.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=572
เผยแพร่โดย (EN):	1 Thalassemia Research Center, Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand 2 Department of Forensic Science, Faculty of Allied Health Sciences, Thammasat University, Pathum Thani, Thailand 3 Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand 4 Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand 5 Department of Cell and Developmental Biology, University of Michigan, Ann Arbor, MI, USA 6 Department of Medical Sciences, National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand
คำสำคัญ (EN):	High-level induction
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science