สืบค้นงานวิจัย
Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand
Wantana Paveenkittiporn - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Wantana Paveenkittiporn
บทคัดย่อ (EN): Group B Streptococcus (GBS) is a leading cause of young infant sepsis and an emerging cause of adult invasive disease. However, data on incidence among adults in middle and low income countries are lacking, and the young infant burden in Southeast Asia has not been characterized. We analysed population-based bloodstream infection data from two provinces in Thailand and sterile site infection data from sentinel hospitals with national representation. Cases were defined as isolation of GBS from blood (population-based surveillance among hospitalized residents of two provinces, 2007-15) or from any sterile site (patients cared for at 25 provincial, regional or private hospitals, 2014-15). Incidence rates in the 2 provinces were calculated using live births (per 1000) for young infants (<3 months of age) or population denominators (per 100,000) for adults (>=18 years). Temporal trends were assessed by linear regression. In the 2 provinces, 10,208 young infants had at least one blood culture (89/1000 live births, median blood volume: 1 ml, interquartile range: 0.5-3.0), yielding 15 GBS cases (80% age 0-6 days). Overall young infant disease incidence was 0.13/1000 live births and by year ranged from 0.0 (2009, 2011, 2013) to 0.36 (2015). Among adults, 373 cases were identified. Adult disease incidence was 5.1/100,000 and increased with age (18-49 years: 2.3, 50-64: 7.4, 65+: 14.3) and over time (2007: 2.6; 2015: 7.8; p= 0.03). In the sentinel hospital system there were 16 young infant cases (88% from blood; 19% age 0-6 days) and 655 adult cases (84% from blood; 38% > 64 years). Among adult cases, 19% had diabetes, 6% renal disease, 6% liver disease, 3% cancer, 3% heart disease; 19% died in hospital and 7% were referred for additional treatment. Predominant serotypes from the sentinel system were III (47%), V (21%) and II (15%). Invasive GBS disease incidence among Thai adults is substantial and comparable to US estimates from 1990-2007: 7.3 per 100,000. Underlying illnesses were less common than in the US (e.g. 19% vs. 44% for diabetes), but clearly play a major role in increasing incidence. The low young infant incidence may reflect incomplete ascertainment, but our estimates are consistent with previous findings from Asia. Further strain characterization is needed to help guide vaccine development.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=666
เผยแพร่โดย (EN): 1 National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand 2 Global Disease Detection Center, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand 3 Kasetsart University Chalermphrakiat, Sakon Nakhon, Thailand 4 Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, USA 5 Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, USA
คำสำคัญ (EN): Thailand
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand
Wantana Paveenkittiporn
1 National Institute of Health, Ministry of Public Health, Nonthaburi, Thailand 2 Global Disease Detection Center, Thailand Ministry of Public Health-US Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand 3 Kasetsart University Chalermphrakiat, Sakon Nakhon, Thailand 4 Division of Bacterial Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, USA 5 Division of Global Health Protection, Center for Global Health, Centers for Disease Control and Prevention, USA
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