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Antioxidant activity and upregulation of antioxidant enzymes of phenolic glycosides from Aquilaria crassna leaves
Supasuteekul C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Antioxidant activity and upregulation of antioxidant enzymes of phenolic glycosides from Aquilaria crassna leaves
ผู้แต่ง / หัวหน้าโครงการ (EN): Supasuteekul C.
บทคัดย่อ (EN): The leaves of Aquilaria crassna Pierre ex Lecomte (Thymelaeaceae) have been used in the traditional medicine and consumed as a health-promoting tea in several Asian countries. This study investigated the antioxidant activity of three major bioactive constituents of A. crassna leaves, genkwanin 5-O-β- primeveroside (1), iriflophenone 3,5-C-β-D-diglucoside (2) and iriflophenone 3-C-β-D-glucoside (3) using DPPH and superoxide scavenging assays, as well as their effects on induction of mRNA and protein expressions of antioxidant enzymes in HEK-293 cells. The benzophenone glycoside 3 exhibited significant scavenging activity against both types of free radicals and increased the mRNA expression of antioxidant enzymes such as glutathione peroxidase-1, glutathione reductase and heme oxygenase-1 in HEK-293 cells. In addition, all three compounds also increased the protein expression of glutathione peroxidase-1. These findings revealed the effects of these compounds at cellular level, and might be useful for the development of A. crassna leaves as supplements for prevention of oxidative stress.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85035243322&partnerID=40&md5=0c5974d0dd270ac74a3dd5a1c91db2ac
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): upregulation
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Antioxidant activity and upregulation of antioxidant enzymes of phenolic glycosides from Aquilaria crassna leaves
Supasuteekul C.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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