สืบค้นงานวิจัย
Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection
Lertjuthaporn S. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection
ผู้แต่ง / หัวหน้าโครงการ (EN): Lertjuthaporn S.
บทคัดย่อ (EN): Dengue virus (DENV) is the most prevalent arthropod-borne viral disease in humans. DENV causes a spectrum of illness ranging from mild to potentially severe complications. Dendritic cells (DCs) play a critical role in initiating and regulating highly effective antiviral immune response that include linking innate and adaptive immune responses. This study was conducted to comparatively characterize in detail the relative proportion, phenotypic changes, and maturation profile of subsets of both myeloid DCs (mDCs) and plasmacytoid DCs (pDCs) in children with dengue fever (DF), dengue hemorrhagic fever (DHF) and for purposes of control healthy individuals. The mDCs (Lin - CD11c + CD123 lo ), the pDCs (Lin - CD11c - CD123 + ) and the double negative (DN) subset (Lin - /HLA - DR + /CD11c - CD123 - ) were analyzed by polychromatic flow cytometry. The data were first analyzed on blood samples collected from DENV-infected patients at various times post-infection. Results showed that the relative proportion of mDCs were significantly decreased which was associated with an increase in disease severity in samples from DENV-infected patients. While there was no significant difference in the relative proportion of pDCs between healthy and DENV-infected patients, there was a marked increase in the DN subset. Analysis of the kinetics of changes of pDCs showed that there was an increase but only during the early febrile phase. Additionally, samples from patients during acute disease showed marked decreases in the relative proportion of CD141 + and CD16 + mDC subsets that were the major mDC subsets in healthy individuals. In addition, there was a significant decrease in the level of CD33-expressing mDCs in DENV patients. While the pDCs showed an up-regulation of maturation profile during acute DENV infection, the mDCs showed an alteration of maturation status. This study suggests that different relative proportion and phenotypic changes as well as alteration of maturation profile of DC subsets may play a critical role in the dengue pathogenesis and disease outcome. © 2018 Lertjuthaporn et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050854709&doi=10.1371%2fjournal.pone.0200564&partnerID=40&md5=d00d4cfbd3caf0a0fe0089d336c09ba6
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Myeloid Cells
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Lertjuthaporn S.. "Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection". ไม่ระบุหน่วยงาน. ม.ป.ป.

Lertjuthaporn S.. "Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



TARR Wordcloud:
Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection
Lertjuthaporn S.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Mitochondrial changes in β0-thalassemia/Hb E disease In vitro generation of dendritic cell - breast cancer cell hybrids for induction of cellular immunity B cell responses during secondary dengue virus infection are dominated by highly cross-reactive, memory-derived plasmablasts Interferon lambda 1 is associated with dengue severity in Thailand Impact of glucose-6-phosphate dehydrogenase deficiency on dengue infection in Myanmar children Periods of high dengue transmission defined by rainfall do not impact efficacy of dengue vaccine in regions of endemic disease Induction of defensin response to dengue infection in Aedes aegypti Recombinase polymerase amplification assay for rapid diagnostics of dengue infection Relationships between dengue virus infection in mosquito vector, (Aedes aegypti), dengue cases and weather conditions in Samut Sakhon Province, Thailand Notch-1 Signaling Mediated Dendritic cells - Induced Autologous NK Cell Proliferation and Cytotoxicity Activity to Cancer Cell
คัดลอก URL
กระทู้ของฉัน
ผลการสืบค้นทั้งหมด โพสต์     เรียงลำดับจาก
พัฒนาระบบโดยศูนย์ความรู้เฉพาะด้านวิศวกรรมความรู้และวิศวกรรมภาษาDeveloped by Center of Excellence for Unified Knowledge and Language Engineering
สนับสนุนโดยสำนักงานพัฒนาการวิจัยการเกษตร (องค์การมหาชน)Supported by the Agricultural Research Development Agency (Public Organization)
แบบสำรวจความพึงพอใจQuestionair