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Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission
Ratana Tacharoenmuang - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission
ผู้แต่ง / หัวหน้าโครงการ (EN): Ratana Tacharoenmuang
บทคัดย่อ (EN): An unusual rotavirus strain, DB2015-066 with the G10P[14] genotype (RVA/Human-wt/THA/DB2015-066/2015/G10P[14]), was detected in a stool sample from a child hospitalized with acute gastroenteritis in Thailand. Here, we sequenced and characterized the full-genome of the strain DB2015-066. On whole genomic analysis, strain DB2015-066 was shown to have a unique genotype constellation: G10-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3. The backbone genes of this strain (I2-R2-C2-M2-A3-N2-T6-E2-H3) are commonly found in rotavirus strains from artiodactyls such as cattle. Furthermore, phylogenetic analysis indicated that each of the 11 genes of strain DB2015-066 could be of artiodactyl (likely bovine) origin. Thus, strain DB2015-066 appeared to be derived from through zoonotic transmission of a bovine rotavirus strain. Of note, the VP7 gene of strain DB2015-066 was located in G10 lineage-6 together with ones of bovine and bovine-like rotavirus strains, away from the clusters comprising other G10P[14] strains in G10 lineage-2/4/5/9, suggesting the occurrence of independent bovine-to-human interspecies transmission events. Our observations provide important insights into the origins of rare G10P[14] strains, and into dynamic interactions between artiodactyl and human rotavirus strains.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=527
เผยแพร่โดย (EN): 1. National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand. 2. Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. 3. Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. 4. Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi 11000, Thailand.
คำสำคัญ (EN): Group A rotaviruses; Whole genomic analysis; Zoonotic transmission; G10P[14] strains; Bovine origin; Thailand
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission
Ratana Tacharoenmuang
1. National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand. 2. Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. 3. Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. 4. Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi 11000, Thailand.
ไม่ระบุวันที่เผยแพร่
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