สืบค้นงานวิจัย
A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings
Xia H. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings
ผู้แต่ง / หัวหน้าโครงการ (EN): Xia H.
บทคัดย่อ (EN): The mechanisms of cellular and humoral immune responses against P. vivax parasite remain poorly understood. Several malaria immunological studies have been conducted in endemic regions where both P. falciparum and P. vivax parasites co-exist. In this study, a comparative analysis of immunity to Plasmodium vivax antigens in different geography and incidence of Plasmodium spp. infection was performed. We characterised antibodies against two P. vivax antigens, PvMSP-1 and PvAMA-1, and the cross-reactivity between these antigens using plasma from acute malaria infected patients living in the central region of China and in the western border of Thailand. P. vivax endemicity is found in central China whereas both P. vivax and P. falciparum are endemic in Thailand. There was an increased level of anti-PvMSP-1/anti-PvAMA-1 in both populations. An elevated level of antibodies to total P. vivax proteins and low level of antibodies to total P. falciparum proteins was found in acute P. vivax infected Chinese, suggesting antibody cross-reactivity between the two species. P. vivax infected Thai patients had both anti-P. vivax and anti-P. falciparum antibodies as expected since both species are present in Thailand. More information on humoral and cell mediated immunity during acute P. vivax-infection in the area where only single P. vivax species existed is of great interest in the relation of building up anti-disease severity caused by P. falciparum. This knowledge will support vaccine development in the future. © 2015, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84938843132&doi=10.17179%2fexcli2015-388&partnerID=40&md5=9b0ec59225817fa163db88eb379eb2e5
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Plasmodium vivax
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Xia H.. "A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings". ไม่ระบุหน่วยงาน. ม.ป.ป.

Xia H.. "A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings
Xia H.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10 Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1 Natural Plasmodium vivax infections in Anopheles mosquitoes in a malaria endemic area of northeastern Thailand Molecular evolution of PvMSP3a block II in Plasmodium vivax from diverse geographic origins Insights into the naturally acquired immune response to Plasmodium vivax malaria Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion STUDY ON THE EFFECT OF POLAR ORGANIC SOLVENT ON REMOVE PROTEIN FROM NATURAL RUBBER Comparative proteomic study of dog and human saliva
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