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Estrogen deficiency leads to further bone loss in the mandible of CKD mice
Guo Y. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Estrogen deficiency leads to further bone loss in the mandible of CKD mice
ผู้แต่ง / หัวหน้าโครงการ (EN): Guo Y.
บทคัดย่อ (EN): Chronic kidney disease (CKD) has been regarded as a grave public health problem. Estrogen is a critical factor for both renal protection and bone remodeling. Our previous study demonstrated that CKD impairs the healing of titanium implants. The aim of this study was to investigate the effects of estrogen deficiency on the mandibular bone in CKD mice. Methods Forty eleven-week-old female C57BL mice were used in this study. Uremia and estrogen deficiency were induced by 5/6 nephrectomy and ovariectomy (OVX), respectively. After 8 weeks, the mice were sacrificed, and their mandibles were collected for micro-CT analysis and histological examination. Results All the mice survived the experimental period. Serum measurements confirmed a significant increase in BUN in the CKD group that was further increased by OVX. OVX led to significant decreases in both the BV/TV and cortical thickness of the mandibular bone in CKD mice. Conclusion In summary, our findings indicate that estrogen deficiency leads to further mandibular bone loss in CKD mice. © 2016 Guo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960533448&doi=10.1371%2fjournal.pone.0148804&partnerID=40&md5=28cd52aff5d4dc82165016260de95739
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): X-Ray Microtomography
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Estrogen deficiency leads to further bone loss in the mandible of CKD mice
Guo Y.
มหาวิทยาลัยมหิดล
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