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Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
Polbuppha I. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
ผู้แต่ง / หัวหน้าโครงการ (EN): Polbuppha I.
บทคัดย่อ (EN): The first phytochemical investigation of the twig extracts of Maclura fruticosa led to the isolation and identification of a new xanthone, maclurafruticosone (1), together with 14 known compounds (2-15). All compounds were elucidated using spectroscopic methods as well as through comparisons made with data reported in the literature. Some isolated compounds were evaluated for their antioxidant, α-glucosidase inhibitory and cytotoxic activities. Compound 4, 6 and 7 showed significant antioxidant activity against DPPH radicals with IC50 values ranging from 7.45-V16.12 μM. Compound 4 also exhibited potent activity against ABTS.,h+ scavenging activity with an IC50 value of 0.55 iÓ 0.01 £gM which was better than positive control (ascorbic acid, IC50 2.35-0.17 μM). Compound 12 showed significant α-glucosidase inhibitory activity with an IC50 value of 0.02-0.37 mM. Compounds 5, 6 and 12 showed weak cytotoxic activities against a colon cancer cell line with IC50 values ranging from 22.35-47.62 μM.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85026481448&partnerID=40&md5=aee2a8e8f276a29b370d01f2043b5428
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): phytochemistry
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Antioxidant, cytotoxic and á-glucosidase inhibitory activities of compounds isolated from the twig extracts of maclura fruticosa
Polbuppha I.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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