สืบค้นงานวิจัย
Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1
Cheng Y. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1
ผู้แต่ง / หัวหน้าโครงการ (EN): Cheng Y.
บทคัดย่อ (EN): In Plasmodium, the membrane of intracellular parasites is initially formed during invasion as an invagination of the red blood cell surface, which forms a barrier between the parasite and infected red blood cells in asexual blood stage parasites. The membrane proteins of intracellular parasites of Plasmodium species have been identified such as early-transcribed membrane proteins (ETRAMPs) and exported proteins (EXPs). However, there is little or no information regarding the intracellular parasite membrane in Plasmodium vivax. In the present study, recombinant PvETRAMP11.2 (PVX-003565) and PvEXP1 (PVX-091700) were expressed and evaluated antigenicity tests using sera from P. vivax-infected patients. A large proportion of infected individuals presented with IgG antibody responses against PvETRAMP11.2 (76.8%) and PvEXP1 (69.6%). Both of the recombinant proteins elicited high antibody titers capable of recognizing parasites of vivax malaria patients. PvETRAMP11.2 partially co-localized with PvEXP1 on the intracellular membranes of immature schizont. Moreover, they were also detected at the apical organelles of newly formed merozoites of mature schizont. We first proposed that these proteins might be synthesized in the preceding schizont stage, localized on the parasite membranes and apical organelles of infected erythrocytes, and induced high IgG antibody responses in patients. © 2015 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960145752&doi=10.1371%2fjournal.pone.0127500&partnerID=40&md5=b40db5cec096e7ce8eca2e76dab9c638
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Young Adult
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Cheng Y.. "Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1". ไม่ระบุหน่วยงาน. ม.ป.ป.

Cheng Y.. "Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1
Cheng Y.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10 Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings Effect of Dietary Protein on Nutrients intake, Nitrogen Balance and Crude protein for Maintenance in Swamp Buffalo CHARACTERIZATION OF LATEX-CLEARING-PROTEIN FROM A RUBBER-DEGRADING BACTERIA ISOLATED IN VIETNAM Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen Monitoring of protein nutrition by milk urea nitrogen and milk protein in Anatolian buffaloes (Buffalo Bulletin (Thailand),35(4)) Rab5, an early endosomal protein required for yellow head virus infection of Penaeus monodon Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand Genetic diversity of Plasmodium falciparum histidine-rich protein 2 in the China-Myanmar border area
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