สืบค้นงานวิจัย
Management and outcomes of severe dengue patients presenting with sepsis in a tropical country
Teparrukkul P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Management and outcomes of severe dengue patients presenting with sepsis in a tropical country
ผู้แต่ง / หัวหน้าโครงการ (EN): Teparrukkul P.
บทคัดย่อ (EN): Dengue is a common cause of infection in adults in tropical countries. Sepsis is a syndrome of systemic manifestations induced by infection of any organisms; including bacterial, fungal and viral agents. Here, we investigated the diagnosis, management and outcomes of dengue patients presenting with sepsis in a prospective study of community-acquired sepsis in Thailand. Methods From June to December 2015, 874 adult patients (age≥18 years) with suspected or documented community-acquired infection, with ≥3 diagnostic criteria for sepsis according to the Surviving Sepsis Campaign 2012, and within 24 hours of admission were evaluated. Serum was stored and later tested for dengue PCR assays. Results A total of 126 patients had dengue PCR assays positive (2 DENV-1, 12 DENV-2, 24 DENV- 3 and 88 DENV-4), and 5 of them (4%) died. We found that attending physicians suspected dengue infection on admission in 84 patients (67%), and recorded dengue infection as the final diagnosis in 96 patients (76%). Four of five fatal cases were diagnosed and treated as septic shock not due to dengue. In multivariable analysis, there was a trend showing that age≥60 years, hypoxemia and misdiagnosis of dengue by attending physicians were associated with 28-day mortality.Conclusions A number of adult patients who died of dengue are misdiagnosed as severe sepsis and septic shock. Diagnosis of dengue based on clinical features alone is difficult. Rapid diagnostic tests for dengue may need to be routinely used in adult patients presenting with sepsis and septic shock in tropical countries. This approach could improve diagnosis and management of those patients. © 2017 Teparrukkul et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85018604148&doi=10.1371%2fjournal.pone.0176233&partnerID=40&md5=591e4fafbd622b2cb22354e540cc7226
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Young Adult
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Teparrukkul P.. "Management and outcomes of severe dengue patients presenting with sepsis in a tropical country". ไม่ระบุหน่วยงาน. ม.ป.ป.

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Management and outcomes of severe dengue patients presenting with sepsis in a tropical country
Teparrukkul P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Microparticles provide a novel biomarker to predict severe clinical outcomes of dengue virus infection Clinical epidemiology and outcomes of community acquired infection and sepsis among hospitalized patients in a resource limited setting in Northeast Thailand: A prospective observational study (Ubon-s Zika Incidence among Patients with Suspected Dengue Fever (Preliminary Report) Intergrated Nutrient Management in Broadcast Seeded Flooded Tropical Rice Temperature of a Dengue Rapid Diagnostic Test under Tropical Climatic Conditions: A Follow Up Study Exposure of a Dengue Vector to Tea and Its Waste: Survival, Developmental Consequences, and Significance for Pest Management Characterization of human CD8 T cell responses in dengue virus-infected patients from India Dengue serotype and clinical severity among pediatric patients : a decade review Low levels of antibody-dependent enhancement in vitro using viruses and plasma from dengue patients Potent neutralizing human monoclonal antibodies preferentially target mature dengue virus particles: Implication for novel strategy for dengue vaccine
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