สืบค้นงานวิจัย
Some pharmacokinetic data and dosage regimen of danofloxacin after intravenous administration in Nili-Ravi and Kundhi buffaloes (Buffalo Bulletin (Thailand),36(2))
Muhammad Abdullah Abid - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Some pharmacokinetic data and dosage regimen of danofloxacin after intravenous administration in Nili-Ravi and Kundhi buffaloes (Buffalo Bulletin (Thailand),36(2))
ผู้แต่ง / หัวหน้าโครงการ (EN): Muhammad Abdullah Abid
หน่วยงานสังกัดผู้แต่ง (EN): Faisalabad (Pakistan). Faculty of Veterinary Science. Department of Physiology and Pharmacology
บทคัดย่อ (EN): Danofloxacin is a fluoroquinolone antibiotic which is extensively used against a variety of bacterial infection in animals worldwide except in Pakistan. The optimal dosage regimen of danofloxacin was necessary in order to use this drug therapeutically and to minimize the emergence of bacterial resistance in local buffaloe breeds in Pakistan. For this, the present study aimed to investigate the pharmacokinetics behavior and optimal dosage regimen of danofloxacin in 16 adult healthy buffaloes, 8 each of Nili-Ravi and Kundhi breed following single intravenous administration at the dose of 2.5 mg/kg body weight. Blood samples (5 ml) were drawn from jugular vein in heparinized plastic centrifuge tubes at zero and 0.083, 0.167, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 10, 12, 24 h after injection and drug concentrations in plasma were measured by HPLC method. The distribution of drug was rapid whereas elimination was low in both breeds. Volume of distribution at steady state (Vss) was significantly (P LT 0.05) higher in Kundhi buffaloes indicating the extensive distribution of danofloxacin in Kundhi than NiliRavi buffaloes. However, the total body area covered by drug was remarkably lower in Kundhi than Nili-Ravi buffaloes as indicated by lower values of area under concentration time curve (AUC) in Kundhi than Nili-Ravi buffaloes. Total body clearance (ClB) was significantly (P LT 0.05) faster in Kundhi buffaloes than Nili-Ravi buffaloes. The mean residence time (MRT) was noted to be (Mean±SD) 4.78±0.52 and 4.44±0.37 h in NiliRavi and Kundhi buffaloes respectively. On the basis of pharmacokinetic parameters, suitable intravenous dosage regimens for danofloxacin in Nili-Ravi and Kundhi buffaloes would be 6.5 and 8.3 mg/kg to be repeated after 12 h intervals. The present study is the foremost pharmacokinetics study of danofloxacin in the local species which would provide the valuable contribution in the local manufacturing of danofloxacin in Pakistan in future.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://kukr.lib.ku.ac.th/db/kukr/search_detail/result/368610
คำสำคัญ (EN): Pakistan
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Muhammad Abdullah Abid. "Some pharmacokinetic data and dosage regimen of danofloxacin after intravenous administration in Nili-Ravi and Kundhi buffaloes (Buffalo Bulletin (Thailand),36(2))". ไม่ระบุหน่วยงาน. ม.ป.ป.

Muhammad Abdullah Abid. "Some pharmacokinetic data and dosage regimen of danofloxacin after intravenous administration in Nili-Ravi and Kundhi buffaloes (Buffalo Bulletin (Thailand),36(2))". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



TARR Wordcloud:
Some pharmacokinetic data and dosage regimen of danofloxacin after intravenous administration in Nili-Ravi and Kundhi buffaloes (Buffalo Bulletin (Thailand),36(2))
Muhammad Abdullah Abid
ไม่ระบุผู้เผยแพร่
ไม่ระบุวันที่เผยแพร่
Uterine didelphys in Nili Ravi buffalo-A case report (Buffalo Bulletin (Thailand),36(4)) Phenotypic characteristics of Sambalpuri buffaloes of India (Buffalo Bulletin (Thailand),36(4)) β(1,4)-Galactosyltransferase-I gene polymorphisms in Pakistani Nili Ravi buffalo (Buffalo Bulletin (Thailand),35(3)) Effect of two management systems and mineral feeding on age at puberty in Nili-Ravi buffalo heifers (Buffalo Bulletin (Thailand),36(1)) Genomic selection of Nili-Ravi buffalo: A choice for buffalo breeders (Buffalo Bulletin (Thailand),35(4)) Study the responses of progesterone administration on resumption of cyclicity on post-partum anestrus buffaloes (Buffalo Bulletin (Thailand),36(1)) Effect of thioglycol on fertility of frozen Nili-Ravi buffalo semen (Buffalo Bulletin (Thailand),35(2)) Oesophageal obstruction in a pregnant buffalo (Buffalo Bulletin (Thailand),36(4)) Incidence of nasal schistosomiasis in graded Murrah buffaloes (Buffalo Bulletin (Thailand),36(1)) Prevalence and risk factors of coccidiosis in buffaloes and cattle from Ravi River region, Lahore, Pakistan (Buffalo Bulletin (Thailand),36(2))
คัดลอก URL
กระทู้ของฉัน
ผลการสืบค้นทั้งหมด โพสต์     เรียงลำดับจาก
พัฒนาระบบโดยศูนย์ความรู้เฉพาะด้านวิศวกรรมความรู้และวิศวกรรมภาษาDeveloped by Center of Excellence for Unified Knowledge and Language Engineering
สนับสนุนโดยสำนักงานพัฒนาการวิจัยการเกษตร (องค์การมหาชน)Supported by the Agricultural Research Development Agency (Public Organization)
แบบสำรวจความพึงพอใจQuestionair