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Zika Incidence among Patients with Suspected Dengue Fever (Preliminary Report)
Jurai Wongsawat - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Zika Incidence among Patients with Suspected Dengue Fever (Preliminary Report)
ผู้แต่ง / หัวหน้าโครงการ (EN): Jurai Wongsawat
บทคัดย่อ (EN): Zika virus infection and its consequences have become increasingly concerned recently. As a member of Flaviviruses, zika virus shares some clinical dengue fever manifestations. The actual burden of zika virus infection in Thailand is unclear, and could be underestimated due to nonspecific clinical pictures and the diagnostic testing has not been routinely available. We aim to study the zika incidence among the suspected dengue fever patients. Methodology: From December 2016 to August 2017, adult and children who had clinical diagnosis of dengue fever at Bamrasnaradura Infectious Diseases Institute were prospectively enrolled. After informed consent, a urine sample would be collected for zika molecular testing by polymerase chain reaction (PCR). At 2 weeks later, a blood sample was collected for zika and dengue serologic tests by ELISA. Results: A total of 73 suspected dengue fever patients were enrolled; 64 were hospitalized, 46 cases were children (< 15 years of age). The ratio of children to adult was 1.7:1. There were 3 confirmed zika-infected cases by urine PCR, a 4.1% incidence. All were adult treated as outpatients. The cases were found during June–August. All 3 cases had positive anti zika IgG (mean titer of 4.43 unit, range: 2.6-6.9 unit), but anti-zika IgM was found to be positive (titer 2.9 unit), indeterminate (titer 0.9 unit) and negative (0.4 unit), one case each. All had negative anti-dengue IgG or IgM titer. Conclusions: The patients presented with dengue fever may actually had zika infection, although at low rate. The anti-zika IgM was not useful in making diagnosis. High risk group such as pregnant women who presented with dengue fever should be tested for zika infection.
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ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=524
เผยแพร่โดย (EN): 1 Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health. 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health. 3 Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University.
คำสำคัญ (EN): Zika virus; dengue fever
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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Zika Incidence among Patients with Suspected Dengue Fever (Preliminary Report)
Jurai Wongsawat
1 Bamrasnaradura Infectious Diseases Institute, Department of Diseases Control, Ministry of Public Health. 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health. 3 Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University.
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