คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Kazuhisa Okada

เผยแพร่โดย

1 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand 2 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan 3 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand 4 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand 5 Department of Pediatrics, Maesot General Hospital, Tak, Thailand 6 Department of Medicine, Maesot General Hospital, Tak, Thailand 7 Department of Community and Social Medicine, Maesot General Hospital, Tak, Thailand 8 Department of Clinical Laboratory, Maesot General Hospital, Tak, Thailand 9 Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand 10 Department of Medicine, Ranong Hospital, Ranong, Thailand 11 Department of Medical Technology, Chum Phae Hospital, Khon Kaen, Thailand 12 Department of Community and Social Medicine, Prapokklao Hospital, Chanthaburi, Thailand 13 Department of Pediatrics, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand 14 Department of Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand 15 Department of Radiology, Samutsakhon Hospital, Samutsakhon, Thailand 16 Department of Pediatrics, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand 17 Department of Preventive and Social Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand 18 Department of Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand 19 Department of Integrated Medicine of Graduate School of Medicine, Osaka University, Osaka, Japan 20 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

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งานวิจัยที่แนะนำ Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Wolbachia supergroups A and B in natural populations of medically important filth flies (Diptera : Muscidae, Calliphoridae, and Sarcophagidae) in Thailand Prevalence of zoonotic Bartonella species among rodents and shrews in Thailand Prevalent emm types and superantigen gene patterns of group A Streptococcus in Thailand. Draft Genome Sequence of a Clostridium botulinum Isolate from Thailand Harboring the Subtype bont/B8 Gene Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand Mangrove forests in Thailand Progress on Rubber Breeding of Thailand

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ชื่อเรื่อง (EN):	Etiologic features of diarrheagenic microbes in stool specimens from patients with acute diarrhea in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN):	Kazuhisa Okada
บทคัดย่อ (EN):	Many microbial species have been recognized as enteropathogens for humans. Here, we predicted the causative agents of acute diarrhea using data from multiplex quantitative PCR (qPCR) assays targeting 19 enteropathogens. For this, a case-control study was conducted at eight hospitals in Thailand. Stool samples and clinical data were collected from 370 hospitalized patients with acute diarrhea and 370 non-diarrheal controls. Multiple enteropathogens were detected in 75.7% and 13.0% of diarrheal stool samples using multiplex qPCR and bacterial culture methods, respectively. Asymptomatic carriers of enteropathogens were found among 87.8% and 45.7% of individuals by qPCR and culture methods, respectively. These results suggested the complexity of identifying causative agents of diarrhea. An analysis using the quantification cut-off values for clinical relevance drastically reduced pathogen-positive stool samples in control subjects from 87.8% to 0.5%, whereas 48.9% of the diarrheal stool samples were positive for any of the 11 pathogens. Among others, rotavirus, norovirus GII, Shigella/EIEC, and Campylobacter were strongly associated with acute diarrhea (P-value < 0.001). Characteristic clinical symptoms, epidemic periods, and age-related susceptibility to infection were observed for some enteropathogens. Investigations based on qPCR approaches covering a broad array of enteropathogens might thus improve our understanding of diarrheal disease etiology and epidemiological trends.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=568
เผยแพร่โดย (EN):	1 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand 2 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan 3 Thailand-Japan Research Collaboration Center on Emerging and Re-emerging Infections, Nonthaburi, Thailand 4 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand 5 Department of Pediatrics, Maesot General Hospital, Tak, Thailand 6 Department of Medicine, Maesot General Hospital, Tak, Thailand 7 Department of Community and Social Medicine, Maesot General Hospital, Tak, Thailand 8 Department of Clinical Laboratory, Maesot General Hospital, Tak, Thailand 9 Department of Medicine, Bamrasnaradura Infectious Diseases Institute, Nonthaburi, Thailand 10 Department of Medicine, Ranong Hospital, Ranong, Thailand 11 Department of Medical Technology, Chum Phae Hospital, Khon Kaen, Thailand 12 Department of Community and Social Medicine, Prapokklao Hospital, Chanthaburi, Thailand 13 Department of Pediatrics, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand 14 Department of Medicine, Sunpasitthiprasong Hospital, Ubon Ratchathani, Thailand 15 Department of Radiology, Samutsakhon Hospital, Samutsakhon, Thailand 16 Department of Pediatrics, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand 17 Department of Preventive and Social Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand 18 Department of Medicine, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand 19 Department of Integrated Medicine of Graduate School of Medicine, Osaka University, Osaka, Japan 20 Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
คำสำคัญ (EN):	Diarrhoea
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science