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Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms
Jovel I.T. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms
ผู้แต่ง / หัวหน้าโครงการ (EN): Jovel I.T.
บทคัดย่อ (EN): Chloroquine resistance in Plasmodium falciparum malaria has been associated with pfcrt 76T (chloroquine resistance transporter gene) and pfmdr1 86Y (multidrug resistance gene 1) alleles. Pfcrt 76T enables transport of protonated chloroquine out of the parasites digestive vacuole resulting in a loss of hydrogen ions (H+). V type H+ pyrophosphatase (PfVP2) is thought to pump H+ into the digestive vacuole. This study aimed to describe the geographic distribution of single nucleotide polymorphisms in pfvp2 and their possible associations with pfcrt and pfmdr1 polymorphisms. Methods: Blood samples from 384 patients collected (1981-2009) in Honduras (n = 35), Colombia (n= 50), Liberia (n= 50), Guinea Bissau (n= 50), Tanzania (n= 50), Iran (n= 50), Thailand (n= 49) and Vanuatu (n= 50) were analysed. The pfcrt 72-76 haplotype, pfmdr1 copy numbers, pfmdr1 N86Y and pfvp2 V405I, K582R and P711S alleles were identified using PCR based methods. Results: Pfvp2 was amplified in 344 samples. The pfvp2 allele proportions were V405 (97%), 405I (3%), K582 (99%), 582R (1%), P711 (97%) and 711S (3%). The number of patients with any of pfvp2 405I, 582R and/or 711S were as follows: Honduras (2/30), Colombia (0/46), Liberia (7/48), Guinea-Bissau (4/50), Tanzania (3/48), Iran (3/50), Thailand (1/49) and Vanuatu (0/31). The alleles were most common in Liberia (P= 0.01) and Liberia. +. Guinea-Bissau (P= 0.01). The VKP haplotype was found in 189/194 (97%) and 131/145 (90%) samples harbouring pfcrt 76T and pfcrt K76 respectively (P= 0.007). Conclusions: The VKP haplotype was dominant. Most pfvp2 405I, 582R and 711S SNPs were seen where CQ resistance was not highly prevalent at the time of blood sampling possibly due to greater genetic variation prior to the bottle neck event of spreading CQ resistance. The association between the pfvp2 VKP haplotype and pfcrt 76T, which may indicate that pfvp2 is involved in CQ resistance, should therefore be interpreted with caution. © 2014 Elsevier B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84897993935&doi=10.1016%2fj.meegid.2014.03.004&partnerID=40&md5=167f5b2f9f115d751a2b11eb5f131f4c
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Sequence Analysis, DNA
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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การอ้างอิง

Jovel I.T.. "Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms". ไม่ระบุหน่วยงาน. ม.ป.ป.

Jovel I.T.. "Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms
Jovel I.T.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
ศึกษา Single Nucleotide Polymorphisms (SNPs) ในโปรโมเตอร์ของยีน accD ในปาล์มน้ำมัน Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene Association between haplotype tagging single nucleotide polymorphisms of the ret proto-oncogene (RET) and hirschsprung disease in thais Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum Diversifying selection on the thrombospondin-related adhesive protein (TRAP) gene of plasmodium falciparum in Thailand Polymorphisms in the MTRN1A gene promoter in buffaloes in the Amazon (Buffalo Bulletin,40(2)) Artemisinin-resistant Plasmodium falciparum malaria β(1,4)-Galactosyltransferase-I gene polymorphisms in Pakistani Nili Ravi buffalo (Buffalo Bulletin (Thailand),35(3)) Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion
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