สืบค้นงานวิจัย
Molecular assays for antimalarial drug resistance surveillance: A target product profile
Nsanzabana C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Molecular assays for antimalarial drug resistance surveillance: A target product profile
ผู้แต่ง / หัวหน้าโครงการ (EN): Nsanzabana C.
บทคัดย่อ (EN): Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasite clearance following treatment with artemisinin derivatives has now spread in the Greater Mekong Sub region and may emerge or spread to other malaria endemic regions. This spread is of great concern for malaria control programmes, as no alternatives to artemisinin-based combination therapies are expected to be available in the near future. There is a need to strengthen surveillance systems for early detection and response to the antimalarial drug resistance threat. Current surveillance is mainly done through therapeutic efficacy studies; however these studies are complex and both time- and resource-intensive. For multiple common antimalarials, parasite drug resistance has been correlated with specific genetic mutations, and the molecular markers associated with antimalarial drug resistance offer a simple and powerful tool to monitor the emergence and spread of resistant parasites. Different techniques to analyse molecular markers associated with antimalarial drug resistance are available, each with advantages and disadvantages. However, procedures are not adequately harmonized to facilitate comparisons between sites. Here we describe the target product profiles for tests to analyse molecular markers associated with antimalarial drug resistance, discuss how use of current techniques can be standardised, and identify the requirements for an ideal product that would allow malaria endemic countries to provide useful spatial and temporal information on the spread of resistance. This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053676487&doi=10.1371%2fjournal.pone.0204347&partnerID=40&md5=e13ab205d48be466324ea74ee9962bfd
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Costs and Cost Analysis
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

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Molecular assays for antimalarial drug resistance surveillance: A target product profile
Nsanzabana C.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Prevalence of Plasmodium falciparum molecular markers of antimalarial drug resistance in a residual malaria focus area in Sabah, Malaysia Prevalence of primary HIV drug resistance in Thailand detected by short reverse transcriptase genotypic resistance assay Detection and drug resistance profile of Escherichia coli from subclinical mastitis cows and water supply in dairy farms in Saraburi Province, Thailand Target product profile for a diagnostic assay to differentiate between bacterial and non-bacterial infections and reduce antimicrobial overuse in resource-limited settings: An expert consensus Genotypic antimicrobial resistance assays for use on E. Coli isolates and stool specimens External Quality Assessment Scheme for HIV-1 Drug Resistance Genotyping in Thailand Chloroquine is grossly under dosed in young children with malaria: Implications for drug resistance Combinatorial Genetic Modeling of pfcrt-Mediated Drug Resistance Evolution in Plasmodium falciparum Use of dried blood spot specimens for in-house HIV drug resistance genotyping assay among infants in Thailand National Survey of Pretreatment HIV-Drug Resistance in Thai HIV-1-Infected Adults
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