สืบค้นงานวิจัย
Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus bin toxin
Tangsongcharoen C. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus bin toxin
ผู้แต่ง / หัวหน้าโครงการ (EN): Tangsongcharoen C.
บทคัดย่อ (EN): Lysinibacillus sphaericus produces the mosquito larvicidal binary toxin consisting of BinA and BinB, which are both required for toxicity against Culex and Anopheles larvae. The molecular mechanisms behind Bin toxin-induced damage remain unexplored. We used whole-genome microarray-based transcriptome analysis to better understand how Culex larvae respond to Bin toxin treatment at the molecular level. Our analyses of Culex quinquefasciatus larvae transcriptome changes at 6, 12, and 18 h after Bin toxin treatment revealed a wide range of transcript signatures, including genes linked to the cytoskeleton, metabolism, immunity, and cellular stress, with a greater number of down-regulated genes than up-regulated genes. Bin toxin appears to mainly repress the expression of genes involved in metabolism, the mitochondrial electron transport chain, and the protein transporter of the outer/inner mitochondrial membrane. The induced genes encode proteins linked to mitochondrial-mediated apoptosis and cellular detoxification including autophagic processes and lysosomal compartments. This study is, to our knowledge, the first microarray analysis of Bin toxin-induced transcriptional responses in Culex larvae, providing a basis for an in-depth understanding of the molecular nature of Bin toxin-induced damage. © 2017 Tangsongcharoen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85017557475&doi=10.1371%2fjournal.pone.0175473&partnerID=40&md5=4a3dfda7425c61b993391ae5866ade09
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Transcription, Genetic
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Tangsongcharoen C.. "Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus bin toxin". ไม่ระบุหน่วยงาน. ม.ป.ป.

Tangsongcharoen C.. "Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus bin toxin". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Molecular analysis of Culex quinquefasciatus larvae responses to Lysinibacillus sphaericus bin toxin
Tangsongcharoen C.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Lysinibacillus sphaericus binary toxin induces apoptosis in susceptible Culex quinquefasciatus larvae Suppression of α-glucosidase gene by RNA interference can increase resistance of Culex quinquefasciatus to Bacillus sphaericus binary toxin Interaction of Lysinibacillus sphaericus binary toxin with mosquito larval gut cells: Binding and internalization Binary toxin subunits of lysinibacillus sphaericus are monomeric and form heterodimers after in vitro activation Development of B-Soy starter for biolarvicide production for control of Culex quinquefasciatus mosquito larvae Larvicidal and histopathological effects of Cassia siamea leaf extract against Culex quinquefasciatus Insecticidal and Behavioral Avoidance Responses of Anopheles minimus and Culex quinquefasciatus (Diptera: Culicidae) to Three Synthetic Repellents Efficiency of Tinospora crispa against Culex quinquefasciatus larva Monitoring of resistance in laboratory susceptible strain and field population strains of Culex quinquefasciatus to Bacillus thuringiensis var. israelensis (Bti), Bacillus sphaericus (Bsph) and temeph Development of larvicidal Bacillus thuringiensis var. israelensis by the Thai NIH and its comparison to Bacillus sphaericus and temephos in a selection experiment with the mosquito Culex quinquefascia
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