คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Komoto

เผยแพร่โดย

1 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 2 Virus Research Institute, National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand 3 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 4 Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 5 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Full genomic analysis of a human G9P[23] rotavirus strain from a child with diarrhea in Thailand Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission Whole Genomic Analysis of an Unusual Human G6P[14] Rotavirus Strain Isolated from a Child with Diarrhea in Thailand: Evidence for Bovine-To-Human Interspecies Transmission and Reassortment Events Top 10 เทรนด์ ในการจัดการความรู้ (KM) Characterization of an unusual DS-1-like G8P[8] rotavirus strain from Japan in 2017: evolution of emerging DS-1-like G8P[8] strains through reassortment 10 Technologies to Watch 2020 Predominant Prevalence of Human Rotaviruses With the G1P[8] and G8P[8] Genotypes With a Short RNA Profile in 2013 and 2014 in Sukhothai and Phetchaboon Provinces, Thailand ผลงานนำเสนอประชุมวิชาการกรมวิทยาศาสตร์การแพทย์ ครั้งที่ 23 เรื่อง สถานการณ์ไข้หวัดใหญ่ปี 2557 เขตบริการสุขภาพที่ 10 ตอนที่ 13 : รางวัลนักวิจัยดีเด่นระดับนานาชาติ และนักวิจัยดีเด่นระดับชาติ ตอนที่ 10 : รางวัลนักวิจัยดีเด่นระดับนานาชาติ และนักวิจัยดีเด่นระดับชาติ

คัดลอก URL

ชื่อเรื่อง (EN):	Whole genomic analysis of bovine group A rotavirus strains A5-10 and A5-13 provides evidence for close evolutionary relationship with human rotaviruses
ผู้แต่ง / หัวหน้าโครงการ (EN):	Komoto
บทคัดย่อ (EN):	Bovine group A rotavirus (RVA) is an important cause of acute diarrhea in calves worldwide. In order to obtain precise information on the origin and evolutionary dynamics of bovine RVA strains, we determined and analyzed the complete nucleotide sequences of the whole genomes of six archival bovine RVA strains; four Thai strains (RVA/Cow-tc/THA/A5-10/1988/G8P[1], RVA/Cow-tc/THA/A5-13/ 1988/G8P[1],RVA/Cow-tc/THA/61A/1989/G10P[5], and RVA/Cow-tc/THA/A44/1989/ G10P[11]),one American strain (RVA/Cow-tc/USA/B223/1983/G10P[11]), and one Japanese strain (RVA/Cow-tc/JPN/KK3/1983/G10P[11]). On whole genomic analysis, the 11 gene segments of strains A5-10, A5-13, 61A, A44, B223, and KK3 were found to be considerably genetically diverse, but to share a conserved non-G/P genotype constellation except for the NSP1 gene (I2-R2-C2-M2-(A3/11/13/14)-N2-T6-E2-H3), which is commonly found in RVA strains from artiodactyls such as cattle. Furthermore, phylogenetic analysis revealed that most genes of the six strains were genetically related to bovine and bovine-like strains. Of note is that the VP1, VP3, and NSP2 genes of strains A5-10 and A5-13 exhibited a closer relationship with the cognate genes of human DS-1-like strains than those of other RVA strains. Furthermore, the VP6 genes of strains A5-10 and A5-13 appeared to be equally related to both human DS-1-like and bovine strains. Thus, strains A5-10 and A5-13 were suggested to be derived from the same evolutionary origin as human DS-1-like strains, and were assumed to be examples of bovine RVA strains that provide direct evidence for a close evolutionary relationship between bovine and human DS-1-like strains. Our findings will provide important insights into the origin of bovine RVA strains, and into evolutionary links between bovine and human RVA strains.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=507
เผยแพร่โดย (EN):	1 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 2 Virus Research Institute, National Institute of Health, Department of Medical Sciences, Nonthaburi 11000, Thailand 3 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 4 Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan 5 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan
คำสำคัญ (EN):	Bovine rotaviruses; Common evolutionary origin; Group A rotaviruses; Human DS-1-like strains; Whole genomic analysis
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science