สืบค้นงานวิจัย
Quantifying low birth weight, preterm birth and small-for- Gestational-age effects of malaria in pregnancy: A population cohort study
Rijken M.J. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Quantifying low birth weight, preterm birth and small-for- Gestational-age effects of malaria in pregnancy: A population cohort study
ผู้แต่ง / หัวหน้าโครงการ (EN): Rijken M.J.
บทคัดย่อ (EN): The association between malaria during pregnancy and low birth weight (LBW) is well described. This manuscript aims to quantify the relative contribution of malaria to small-for-gestational-age (SGA) infants and preterm birth (PTB) in pregnancies accurately dated by ultrasound on the Thai-Myanmar border at the Shoklo Malaria Research Unit. Methods and Findings: From 2001 to 2010 in a population cohort of prospectively followed pregnancies, we analyzed all singleton newborns who were live born, normal, weighed in the first hour of life and with a gestational age (GA) between 28+0 and 41+6 weeks. Fractional polynomial regression was used to determine the mean birthweight and standard deviation as functions of GA. Risk differences and factors of LBW and SGA were studied across the range of GA for malaria and non-malaria pregnancies. From 10,264 newborns records, population centiles were created. Women were screened for malaria by microscopy a median of 22 [range 1-38] times and it was detected and treated in 12.6% (1,292) of pregnancies. Malaria was associated with LBW, PTB, and SGA compared to those without malaria. Nearly two-thirds of PTB were classified as LBW (68% (539/789)), most of which 83% (447/539) were not SGA. After GA 39 weeks, 5% (298/5,966) of non-LBW births were identified as SGA. Low body mass index, primigravida, hypertension, smoking and female sex of the newborn were also significantly and independently associated with LBW and SGA consistent with previous publications. Conclusions: Treated malaria in pregnancy was associated with an increased risk for LBW, PTB, and SGA, of which the latter are most important for infant survival. Using LBW as an endpoint without adjusting for GA incorrectly estimated the effects of malaria in pregnancy. Ultrasound should be used for dating pregnancies and birth weights should be expressed as a function (or adjusted for GA) of GA in future malaria in pregnancy studies. © 2014 Rijken et al.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903749769&doi=10.1371%2fjournal.pone.0100247&partnerID=40&md5=1aa52822e4266cc927b794a2820973e9
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Sex Factors
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Rijken M.J.. "Quantifying low birth weight, preterm birth and small-for- Gestational-age effects of malaria in pregnancy: A population cohort study". ไม่ระบุหน่วยงาน. ม.ป.ป.

Rijken M.J.. "Quantifying low birth weight, preterm birth and small-for- Gestational-age effects of malaria in pregnancy: A population cohort study". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



TARR Wordcloud:
Quantifying low birth weight, preterm birth and small-for- Gestational-age effects of malaria in pregnancy: A population cohort study
Rijken M.J.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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