คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Wantana Paveenkittiporn

เผยแพร่โดย

1 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Thailand 2 Faculty of Public Health, Kasetsart University, Sakon Nakhon, Thailand

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หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Draft Genome Sequence of a Clostridium botulinum Isolate from Thailand Harboring the Subtype bont/B8 Gene Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand Wolbachia supergroups A and B in natural populations of medically important filth flies (Diptera : Muscidae, Calliphoridae, and Sarcophagidae) in Thailand Prevalence of zoonotic Bartonella species among rodents and shrews in Thailand Whole-genome sequence analysis of Zika virus isolated from the plasma of an infected patient in Thailand Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand Molecular Epidemiology of Carbapenem-Resistant Enterobacterales in Thailand, 20162018. Mangrove forests in Thailand Draft Genome Sequence of Invasive Salmonella enterica Serovar Cannstatt Harboring mcr-1.1, Isolated from a Fatal Sepsis Case

คัดลอก URL

ชื่อเรื่อง (EN):	Whole-Genome Sequencing of Clinically Isolated Carbapenem-Resistant Enterobacterales Harboring mcr Genes in Thailand, 2016-2019
ผู้แต่ง / หัวหน้าโครงการ (EN):	Wantana Paveenkittiporn
บทคัดย่อ (EN):	Mobile colistin-resistant genes (mcr) have become an increasing public health concern. Since the first report of mcr-1 in Thailand in 2016, perspective surveillance was conducted to explore the genomic characteristics of clinical carbapenem-resistant Enterobacterales (CRE) isolates harboring mcr in 2016–2019. Thirteen (0.28%) out of 4,516 CRE isolates were found to carry mcr genes, including 69.2% (9/13) of E. coli and 30.8% (4/13) of K. pneumoniae isolates. Individual mcr-1.1 was detected in eight E. coli (61.5%) isolates, whereas the co-occurrence of mcr-1.1 and mcr-3.5 was seen in only one E. coli isolate (7.7%). No CRE were detected carrying mcr-2, mcr-4, or mcr-5 through to mcr-9. Analysis of plasmid replicon types carrying mcr revealed that IncX4 was the most common (61.5%; 8/13), followed by IncI2 (15.4%; 2/13). The minimum inhibitory concentration values for colistin were in the range of 4–16 μg/ml for all CRE isolates harboring mcr, suggesting they have 100% colistin resistance. Clermont phylotyping of nine mcr-harboring carbapenem-resistant E. coli isolates demonstrated phylogroup C was predominant in ST410. In contrast, ST336 belonged to CC17, and the KL type 25 was predominant in carbapenem-resistant K. pneumoniae isolates. This report provides a comprehensive insight into the prevalence of mcr-carrying CRE from patients in Thailand. The information highlights the importance of strengthening official active surveillance efforts to detect, control, and prevent mcr-harboring CRE and the need for rational drug use in all sectors.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=735
เผยแพร่โดย (EN):	1 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Thailand 2 Faculty of Public Health, Kasetsart University, Sakon Nakhon, Thailand
คำสำคัญ (EN):	Genome
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science