สืบค้นงานวิจัย
Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostrea cucullata
Khondee P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostrea cucullata
ผู้แต่ง / หัวหน้าโครงการ (EN): Khondee P.
บทคัดย่อ (EN): Tributyltin (TBT), an environmental pollutant in marine ecosystems, is toxic to organisms. Although contamination by and bioaccumulation and toxicity of this compound have been widely reported, its underlying molecular mechanisms remain unclear. In the present study, we exposed the Hooded oyster Saccostrea cucullata to TBT to investigate histopathological effects and proteome stress response. Animals were exposed to three TBT sub-lethal concentrations, 10, 50 and 150 μg/l for 48 h. TBT produced stress leading to histopathological changes in oyster tissues including mantle, gill, stomach and digestive diverticula. TBT induced mucocyte production in epithelia and hemocyte aggregation in connective tissue. Cell necrosis occurred when exposure dosages were high. Comparative proteome analyses of mantle protein of oysters exposed to 10 μg/l and control animals were analyzed by a 2-DE based proteomic approach. In total, 32 protein spots were found to differ (p < 0.05). Of these, 17 proteins were identified which included 14 up-regulated and 3 down-regulated proteins. TBT induced the expression of proteins involved in defensive mechanisms (HSP-78, HSP-70, aldehyde dehydrogenase and catalase), calcium homeostasis (VDAC-3), cytoskeleton and cytoskeleton-associated proteins, energy metabolism and amino acid metabolism. Our study revealed that TBT disturbs calcium homeostasis via VDAC-3 protein in mantle and this probably is the key molecular mechanism of TBT acting to distort shell calcification. Moreover, proteins involved in cell structure (tubulin-alpha and tubulin-beta) and protein synthesis were reduced after TBT exposure. Additionally, differential proteins obtained from this work will be useful as potential TBT biomarkers. © 2016 Elsevier Ltd
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84991811300&doi=10.1016%2fj.envpol.2016.08.011&partnerID=40&md5=da34a4d161fd5ab4821abbc0c3b10306
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Water Pollutants, Chemical
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Khondee P.. "Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostrea cucullata". ไม่ระบุหน่วยงาน. ม.ป.ป.

Khondee P.. "Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostrea cucullata". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Histopathological effect and stress response of mantle proteome following TBT exposure in the Hooded oyster Saccostrea cucullata
Khondee P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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