สืบค้นงานวิจัย
Molecular epidemiology of Clostridium difficile infection in a large teaching hospital in Thailand
Ngamskulrungroj P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Molecular epidemiology of Clostridium difficile infection in a large teaching hospital in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Ngamskulrungroj P.
บทคัดย่อ (EN): Clostridium difficile infection (CDI) is a leading cause of healthcare-associated morbidity and mortality worldwide. In Thailand, CDI exhibits low recurrence and mortality and its molecular epidemiology is unknown. CDI surveillance was conducted in a tertiary facility (Siriraj Hospital, Bangkok). A total of 53 toxigenic C. difficile strains from Thai patients were analyzed by multi-locus sequence typing (MLST), PCR ribotyping, and pulse-field gel electrophoresis (PFGE). The mean age of the cohort was 64 years and 62.3% were female; 37.7% of patients were exposed to > two antibiotics prior to a diagnosis of CDI, with beta-lactams the most commonly used drug (56.3%). Metronidazole was used most commonly (77.5%; success rate 83.9%), and non-responders were treated with vancomycin (success rate 100%). None of the isolates carried binary toxin genes. Most isolates (98.2-100%) were susceptible to metronidazole, vancomycin, tigecycline and daptomycin. There were 11 sequence types (STs), 13 ribotypes (RTs) and four PFGE types. Six previously identified STs (ST12, ST13, ST14, ST33, ST41 and ST45) and five novel STs unique to Thailand (ST66, ST67, ST68, ST69 and ST70) were identified. PCR RTs UK 017 (ST45) (45.3%) and UK 014/020 (ST33) (24.5%) were the most common. High concordance was observed between the MLST and ribotyping results (p<0.001). C. difficile isolates from Thai patients were highly susceptible to standard antimicrobial agents. In conclusion, the five STs indicate the high genetic diversity and unique polymorphisms in Thailand. Moreover, the emergence of antimicrobial resistance to vancomycin warranted continuous surveillance to prevent further spread of the toxigenic C. difficile isolates. © 2015 Ngamskulrungroj et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84930619754&doi=10.1371%2fjournal.pone.0127026&partnerID=40&md5=1b215b7e07e2982104fa9b53d3b6258f
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Thailand
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Ngamskulrungroj P.. "Molecular epidemiology of Clostridium difficile infection in a large teaching hospital in Thailand". ไม่ระบุหน่วยงาน. ม.ป.ป.

Ngamskulrungroj P.. "Molecular epidemiology of Clostridium difficile infection in a large teaching hospital in Thailand". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Molecular epidemiology of Clostridium difficile infection in a large teaching hospital in Thailand
Ngamskulrungroj P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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