คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Sittiporn Parnmen

เผยแพร่โดย

1 Toxicology Center, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, 11000, Thailand 2 Department of Microbiology, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand 3 Department of Biology, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand

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หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Characterization and identification of Hb Bart's hydrops fetalis caused by a compound heterozygous mutation --SEA /--CR , a novel α0 -thalassemia deletion [แก้ไข] Forest mushroom เห็ดชนิดนี้หน้าตาคล้ายเห็ดคางคก ไม่แนะนำให้กิน การวิเคราะห์สารอัลคาลอยด์มัสคาลีนในเห็ดพิษด้วยวิธี Liquid Chromatography-tandem Mass Spectrometry (LC-MS/MS) An Analysis of alkaloid muscarine-containing mushrooms using liquid chromatography-tandem m Analysis of Ascorbic Acid and Isoascorbic Acid in Orange and Guava Fruit Juices Distributed in Thailand by LC-IT-MS/MS Development and validation of LC-MS/MS method for quantitative determination of adenosine, guanosine, xanthine and uric acid in widely consumed vegetables in Thailand การพัฒนาวิธีเตรียมตัวอย่างเลือดเพื่อจำแนกเชื้อแบคทีเรียโดยตรงด้วย MALDI-TOF MS Development of blood sample preparation method for direct bacterial identification using MALDI-TOF MS ผลของสภาวะการเพาะเลี้ยงต่อการจำแนกเชื้อบาซิลลัสแอนทราซิสด้วยเทคนิค MALDI-TOF MS Effects of culture conditions for Bacillus anthracis identification based on MALDI-TOF MS Qualitative and quantitative comparison of the proteome of erythroid cells differentiated from human iPSCs and adult erythroid cells by multiplex TMT labelling and nanoLC-MS/MS Molecular identification of poisonous mushrooms using nuclear ITS region and peptide toxins: a retrospective study on fatal cases in Thailand ฤทธิ์การยับยั้งเชื้อแบคทีเรียก่อโรคที่ผิวหนังและความเป็นพิษต่อเซลล์ของสารสกัดจากกะเม็ง (Eclipta prostrata Linn.) และว่านพระฉิม (Dioscorea bulbifera Linn.) และการตรวจวิเคราะห์สารโดยใช้เทคนิค Liquid chr

คัดลอก URL

ชื่อเรื่อง (EN):	Foodborne illness caused by muscarine-containing mushrooms and identification of mushroom remnants using phylogenetics and LC-MS/MS
ผู้แต่ง / หัวหน้าโครงการ (EN):	Sittiporn Parnmen
บทคัดย่อ (EN):	A 9-year analysis of wild mushroom consumption in Thailand during 2010–2018 revealed 61 patients from 14 cases exhibiting mushroom poisoning most likely from foraged mushrooms in the family Inocybaceae. Fifty-four patients experienced neurotoxic syndromes, while seven patients presented symptoms relating to gastrointestinal irritant mushroom poisoning. The causative agents for this foodborne illness were primarily recognised based on mushroom samples left from food preparation. These remnants however, lacked sufficient information for accurate taxon identification. Hence, this study aimed to characterise the suspected mushroom samples obtained from clinically reported cases based on multi-locus sequence data and toxic alkaloid diagnosis. Multi-locus phylogenetic analyses were conducted using maximum likelihood and Bayesian approaches. The resulting concatenated phylogenetic trees confirmed that all 26 clinical samples of mushrooms belonged to the family Inocybaceae, and were clustered into highly supported clades of Inocybe, Inosperma and Pseudosperma. In addi- tion, LC-MS/MS detection revealed the presence of alkaloid muscarine as the major toxic substance in all samples of Inosperma and Pseudosperma. Ingestion of these muscarine-containing mushrooms showed a short latent period with signs of perspiration, hypersalivation, lachrymation, bradycardia, diarrhoea and fatigue. Consumption of Inocybe did not reveal these muscarinic symptoms, but the patients experienced similar toxicity effects to gastrointestinal irritant mushroom poisoning, including nausea, vomiting, intestinal colic and xerostomia. Data on molecular annotation and toxic chemical composition of the wild poisonous mushrooms obtained in this study are relevant for food safety and also required for better medical treatment decision making.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=742
เผยแพร่โดย (EN):	1 Toxicology Center, National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, 11000, Thailand 2 Department of Microbiology, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand 3 Department of Biology, Faculty of Science, Srinakharinwirot University, Bangkok, 10110, Thailand
คำสำคัญ (EN):	Mushroom poisoning
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science