คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Ratana Tacharoenmuang

เผยแพร่โดย

1 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand, 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan, 3 Department of Virology II, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan, 4 Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan, 5 Genome and Transcriptome Analysis Center, Fujita Health University, Toyoake, Aichi, Japan, 6 Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Human rotavirus surveillance in hospitalized gastroenteritis cases in Bangkok, Thailand during 2015 - 2018 Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Full Genome Characterization of Novel DS-1-Like G8P[8] Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Re Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand Characterization of a G10P[14] rotavirus strain from a diarrheic child in Thailand: Evidence for bovine-to-human zoonotic transmission 10 สุดยอดแนวโน้มเทคโนโลยีเชิงกลยุทธ์สำหรับปี 2020 โดย Gartner The series EP. 4 : Human augmentation Full genome-based characterization of G4P[6] rotavirus strains from diarrheic patients in Thailand: Evidence for independent porcine-to-human interspecies transmission events Full genomic analysis of a human G9P[23] rotavirus strain from a child with diarrhea in Thailand Detection, identification and characterization of enteric bacterial pathogens in a case-control study of acute diarrhea in Thailand Whole-genome sequence analysis of Zika virus isolated from the plasma of an infected patient in Thailand

คัดลอก URL

ชื่อเรื่อง (EN):	Whole Genomic Analysis of an Unusual Human G6P[14] Rotavirus Strain Isolated from a Child with Diarrhea in Thailand: Evidence for Bovine-To-Human Interspecies Transmission and Reassortment Events
ผู้แต่ง / หัวหน้าโครงการ (EN):	Ratana Tacharoenmuang
บทคัดย่อ (EN):	An unusual rotavirus strain, SKT-27, with the G6P[14] genotypes (RVA/Human-wt/THA/ SKT-27/2012/G6P[14]), was identified in a stool specimen from a hospitalized child aged eight months with severe diarrhea. In this study, we sequenced and characterized the complete genome of strain SKT-27. On whole genomic analysis, strain SKT-27 was found to have a unique genotype constellation: G6-P[14]-I2-R2-C2-M2-A3-N2-T6-E2-H3. The non- G/P genotype constellation of this strain (I2-R2-C2-M2-A3-N2-T6-E2-H3) is commonly shared with rotavirus strains from artiodactyls such as cattle. Phylogenetic analysis indicated that nine of the 11 genes of strain SKT-27 (VP7, VP4, VP6, VP2-3, NSP1, NSP3-5) appeared to be of artiodactyl (likely bovine) origin, while the remaining VP1 and NSP2 genes were assumed to be of human origin. Thus, strain SKT-27 was found to have a bovine rotavirus genetic backbone, and thus is likely to be of bovine origin. Furthermore, strain SKT-27 appeared to be derived through interspecies transmission and reassortment events involving bovine and human rotavirus strains. Of note is that the VP7 gene of strain SKT-27 was located in G6 lineage-5 together with those of bovine rotavirus strains, away from the clusters comprising other G6P[14] strains in G6 lineages-2/6, suggesting the occurrence of independent bovine-to-human interspecies transmission events. To our knowledge, this is the first report on full genome-based characterization of human G6P[14] strains that have emerged in Southeast Asia. Our observations will provide important insights into the origin of G6P[14] strains, and into dynamic interactions between human and bovine rotavirus strains.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=483
เผยแพร่โดย (EN):	1 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand, 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan, 3 Department of Virology II, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan, 4 Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan, 5 Genome and Transcriptome Analysis Center, Fujita Health University, Toyoake, Aichi, Japan, 6 Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
คำสำคัญ (EN):	Bovine-To-Human
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science