สืบค้นงานวิจัย
Molecular evolution of PvMSP3a block II in Plasmodium vivax from diverse geographic origins
Gupta B. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Molecular evolution of PvMSP3a block II in Plasmodium vivax from diverse geographic origins
ผู้แต่ง / หัวหน้าโครงการ (EN): Gupta B.
บทคัดย่อ (EN): Block II of Plasmodium vivax merozoite surface protein 3α (PvMSP3α) is conserved and has been proposed as a potential candidate for a malaria vaccine. The present study aimed to compare sequence diversity in PvMSP3a block II at a local microgeographic scale in a village as well as from larger geographic regions (countries and worldwide). Blood samples were collected from asymptomatic carriers of P. vivax in a village at the western border of Thailand and PvMSP3α was amplified and sequenced. For population genetic analysis, 237 PvMSP3α block II sequences from eleven P. vivax endemic countries were analyzed. PvMSP3α sequences from 20 village-level samples revealed two length variant types with one type containing a large deletion in block I. In contrast, block II was relatively conserved; especially, some non-synonymous mutations were extensively shared among 11 parasite populations. However, the majority of the low-frequency synonymous variations were population specific. The conserved pattern of nucleotide diversity in block II sequences was probably due to functional/structural constraints, which were further supported by the tests of neutrality. Notably, a small region in block II that encodes a predicted B cell epitope was highly polymorphic and showed signs of balancing selection, signifying that this region might be influenced by the immune selection and may serve as a starting point for designing multi-antigen/stage epitope based vaccines against this parasite. © 2015 Gupta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84943172094&doi=10.1371%2fjournal.pone.0135396&partnerID=40&md5=21dea6290ddf6713440bd80855a0db86
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Protozoan Proteins
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Gupta B.. "Molecular evolution of PvMSP3a block II in Plasmodium vivax from diverse geographic origins". ไม่ระบุหน่วยงาน. ม.ป.ป.

Gupta B.. "Molecular evolution of PvMSP3a block II in Plasmodium vivax from diverse geographic origins". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Molecular evolution of PvMSP3a block II in Plasmodium vivax from diverse geographic origins
Gupta B.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion Genetic diversity of the Plasmodium vivax multidrug resistance 1 gene in Thai parasite populations Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10 Insights into the naturally acquired immune response to Plasmodium vivax malaria Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates Evolution of Fseg/Cseg dimorphism in region III of the Plasmodium falciparum eba-175 gene Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen ศักยภาพของยีน DNA-directed RNA polymerase II subunit (RPB1) ในการเป็น molecular marker สำหรับการตรวจสอบเห็ดพิษ Amanita Potential of the DNA-directed RNA polymerase II subunit (RPB1) gene as a molecula
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