สืบค้นงานวิจัย
Lack of genotoxic potential of ZnO nanoparticles in in vitro and in vivo tests
Kwon J.Y. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Lack of genotoxic potential of ZnO nanoparticles in in vitro and in vivo tests
ผู้แต่ง / หัวหน้าโครงการ (EN): Kwon J.Y.
บทคัดย่อ (EN): The industrial application of nanotechnology, particularly using zinc oxide (ZnO), has grown rapidly, including products such as cosmetics, food, rubber, paints, and plastics. However, despite increasing population exposure to ZnO, its potential genotoxicity remains controversial. The biological effects of nanoparticles depend on their physicochemical properties. Preparations with well-defined physico-chemical properties and standardized test methods are required for assessing the genotoxicity of nanoparticles. In this study, we have evaluated the genotoxicity of four kinds of ZnO nanoparticles: 20. nm and 70. nm size, positively or negatively charged. Four different genotoxicity tests (bacterial mutagenicity assay, in vitro chromosomal aberration test, in vivo comet assay, and in vivo micronucleus test, were conducted, following Organization for Economic Cooperation and Development (OECD) test guidelines with good laboratory practice (GLP) procedures. No statistically significant differences from the solvent controls were observed. These results suggest that surface-modified ZnO nanoparticles do not induce genotoxicity in in vitro or in vivo test systems. © 2014 Elsevier B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84893743466&doi=10.1016%2fj.mrgentox.2014.01.005&partnerID=40&md5=bfdfd1ae6dc00ce3a396d31c0aceef08
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Zinc Oxide
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Kwon J.Y.. "Lack of genotoxic potential of ZnO nanoparticles in in vitro and in vivo tests". ไม่ระบุหน่วยงาน. ม.ป.ป.

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Lack of genotoxic potential of ZnO nanoparticles in in vitro and in vivo tests
Kwon J.Y.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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