สืบค้นงานวิจัย
Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma
Fard M.A. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma
ผู้แต่ง / หัวหน้าโครงการ (EN): Fard M.A.
บทคัดย่อ (EN): Purpose Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thickness. Methods 31 chronic NAION (>6 months after the acute event) and unaffected fellow eyes (31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes (46 healthy subjects) were imaged with a commercial optical coherence tomography angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic institutions. Two concentric circles of diameters 1.95mm (inner) and 3.45mm (outer) were manually placed on images centered on the optic nerve head, producing an annular region-of-interest. Image analysis with major vessel removal was performed using a custom program. Whole-image, whole-annulus, and sectoral PCDs were measured. Results Whole-image and whole-annulus PCDs in NAION and moderate and severe POAG eyes were significantly decreased compared to unaffected fellow eyes and control eyes (all P<0.001). Superior and temporal PCD values were affected more than other sectors in both NAION and POAG groups compared to control group. Whole-image and whole-annulus PCDs were not statistically different between NAION and POAG eyes (both P = 0.99). However, of all peripapillary sectors, the inferior sector PCD value was less affected in POAG eyes compared to NAION eyes (P = 0.001). Univariate analysis results also revealed a significant positive correlation between superior and inferior PCDs and corresponding RNFL thicknesses. The inferior sector correlation was greater in POAG than NAION eyes. Conclusion While the whole PCD values were not different in chronic NAION and POAG, the greater correlation of inferior PCD with corresponding RNFL sectors in POAG compared to NAION suggests greater susceptibility of the inferior radial peripapillary capillary in the pathogenesis of POAG. © This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040368606&doi=10.1371%2fjournal.pone.0189237&partnerID=40&md5=e44060250f1de02dc8799594781b3e4a
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Optic Neuropathy, Ischemic
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

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Fard M.A.. "Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma". ไม่ระบุหน่วยงาน. ม.ป.ป.

Fard M.A.. "Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Pattern of peripapillary capillary density loss in ischemic optic neuropathy compared to that in primary open-angle glaucoma
Fard M.A.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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