คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Supathra Tiewcharoen

เผยแพร่โดย

1 Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. 2 Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom, Thailand. 3 Center of Nanoimaging, Faculty of Science, Mahidol University, Bangkok, Thailand. 4 Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand. 5 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand.

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Full genomic analysis of a human G9P[23] rotavirus strain from a child with diarrhea in Thailand Observed Changes in the Climate Extremes over Tripura, Northeast India PESTICIDES USED IN THAILAND AND TOXIC EFFECTS TO HUMAN HEALTH Effect of synthetic antimicrobial peptides on Naegleria fowleri trophozoites Comparison of gene expression profiles between human erythroid cells derived from fetal liver and adult peripheral blood In vitro production of functional immune cells derived from human hematopoietic stem cells Modulation of vaccine-induced CD4 T cell functional profiles by changes in components of HIV vaccine regimens in humans A time course analysis of the electrophysiological properties of neurons differentiated from human induced Pluripotent Stem Cells (iPSCs) ฤทธิ์ทางชีวภาพต่อเซลล์ human skin fibroblast และ B16F10 melanoma ของสารสกัด รวงข้าวขาวดอกมะลิ 105 ฤทธิ์ทางชีวภาพต่อเซลล์ human skin fibroblast และ B16F10 melanoma ของสารสกัด รวงข้าวขาวดอกมะลิ 10

คัดลอก URL

ชื่อเรื่อง (EN):	Ultra Structure changes of diosgenin-treated human monocyte U937-derived macrophages induced by naegleria fowleri lysate
ผู้แต่ง / หัวหน้าโครงการ (EN):	Supathra Tiewcharoen
บทคัดย่อ (EN):	Diosgenin has anti-amoebic activity against Naegleria fowleri and antiinflammatory activity in human monocyte U937-derived macrophages incubated with Naegleria lysate. In order to better understand the mode of action of diosgenin, human monocyte U937-derived macrophages were induced by N. fowleri lysate and investigated using scanning electron microscopy (SEM). SEM revealed orphological changes of human monocyte U937-derived macrophages in size, shape, cytoplasmic extensions and microvilli. The formation of the disrupted membrane structure occurred in a time-dependent manner. No significant differences in cell morphology were observed between diosgenin-treated samples and untreated cells; however, macrophages induced by N. fowleri lysate or lipopolysaccharide (LPS) were completely damaged by 48 hours of incubation. Diosgenin-treated macrophages induced by N. fowleri lysate and LPS had thorn-like protrusions from filopodia and lamilipodia. Our findings show the affect of diosgenin at the ultracellular level.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=522
เผยแพร่โดย (EN):	1 Department of Parasitology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. 2 Department of Biology, Faculty of Science, Silpakorn University, Nakhon Pathom, Thailand. 3 Center of Nanoimaging, Faculty of Science, Mahidol University, Bangkok, Thailand. 4 Institute of Molecular Biosciences, Mahidol University, Nakhon Pathom, Thailand. 5 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand.
คำสำคัญ (EN):	Diosgenin; Naegleria fowleri lysate; human monocyte U937-derived Macrophage; scanning electron micrograph
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science