สืบค้นงานวิจัย
Population structure shapes copy number variation in malaria parasites
Cheeseman I.H. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Population structure shapes copy number variation in malaria parasites
ผู้แต่ง / หัวหน้าโครงการ (EN): Cheeseman I.H.
บทคัดย่อ (EN): If copy number variants (CNVs) are predominantly deleterious, we would expect them to be more efficiently purged from populations with a large effective population size (N e ) than from populations with a small N e . Malaria parasites (Plasmodium falciparum) provide an excellent organism to examine this prediction, because this protozoan shows a broad spectrum of population structures within a single species, with large, stable, outbred populations in Africa, small unstable inbred populations in South America and with intermediate population characteristics in South East Asia. We characterized 122 single-clone parasites, without prior laboratory culture, from malaria-infected patients in seven countries in Africa, South East Asia and South America using a high-density single-nucleotide polymorphism/CNV microarray. We scored 134 high-confidence CNVs across the parasite exome, including 33 deletions and 102 amplifications, which ranged in size from <500 bp to 59 kb, as well as 10,107 flanking, biallelic single-nucleotide polymorphisms. Overall, CNVs were rare, small, and skewed toward low frequency variants, consistent with the deleterious model. Relative to African and South East Asian populations, CNVs were significantly more common in South America, showed significantly less skew in allele frequencies, and were significantly larger. On this background of low frequency CNV, we also identified several high-frequency CNVs under putative positive selection using an F ST outlier analysis. These included known adaptive CNVs containing rh2b and pfmdr1, and several other CNVs (e.g., DNA helicase and three conserved proteins) that require further investigation. Our data are consistent with a significant impact of genetic structure on CNV burden in an important human pathogen. © The Author 2015. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.
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ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84964494870&doi=10.1093%2fmolbev%2fmsv282&partnerID=40&md5=65c65da5a9e2595ba18821670625b56d
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Selection, Genetic
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Cheeseman I.H.. "Population structure shapes copy number variation in malaria parasites". ไม่ระบุหน่วยงาน. ม.ป.ป.

Cheeseman I.H.. "Population structure shapes copy number variation in malaria parasites". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Population structure shapes copy number variation in malaria parasites
Cheeseman I.H.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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