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Expression and structural variations of toll-like receptor 4 gene in buffalo and cattle (Buffalo Bulletin,41(1))
Balanehru Subramanian - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Expression and structural variations of toll-like receptor 4 gene in buffalo and cattle (Buffalo Bulletin,41(1))
ผู้แต่ง / หัวหน้าโครงการ (EN): Balanehru Subramanian
หน่วยงานสังกัดผู้แต่ง (EN): Puducherry (India). Central Inter-Disciplinary Research Facility (CIDRF)
บทคัดย่อ (EN): Systematic studies on expression and characterization of toll like receptors (TLRs) in buffalo and cattle will help to understand the innate immune response specific to each species of animals. TLR4 gene is one of the most studied innate immune receptors which is mainly triggered by lipopolysaccharide. Therefore, the present study was carried out to investigate the mRNA expression and sequence analysis of TLR4 in buffalo in comparison to that of cattle. In vitro expression of TLR4 was assessed by challenging the Peripheral Blood Mononuclear Cells (PBMC) with bacterial LPS which showed significant increase of TLR4 gene expression (P LT= 0.01) in buffaloes when compared to cattle. Further the comparison of mRNA sequence of TLR4 of buffalo and cattle revealed 96 percent similarity with the cattle sequence. The primary structure of protein showed the highest percent of leucine amino acid for both the species of animals. At the same time, the number of Leucine Rich repeats (LRR) of buffalo is varied from those present in cattle TLR4. Alpha helix is the prominent secondary structure, however, there were few amino acid variations between buffalo and cattle in certain regions of TLR4 which altered the three dimensional conformation of TLR4 proteins, this in-turn possibly can influence the binding affinity and interaction with pathogens which may influence the difference in immune response in buffalo when compared to that of cattle.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://kukr.lib.ku.ac.th/db/kukr/search_detail/result/416660
คำสำคัญ (EN): India
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Balanehru Subramanian. "Expression and structural variations of toll-like receptor 4 gene in buffalo and cattle (Buffalo Bulletin,41(1))". ไม่ระบุหน่วยงาน. ม.ป.ป.

Balanehru Subramanian. "Expression and structural variations of toll-like receptor 4 gene in buffalo and cattle (Buffalo Bulletin,41(1))". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Expression and structural variations of toll-like receptor 4 gene in buffalo and cattle (Buffalo Bulletin,41(1))
Balanehru Subramanian
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Molecular characterization of buffalo alpha s1-casein gene (Buffalo Bulletin,41(3)) Hydrallantois in a graded Murrah buffalo - A case report (Buffalo Bulletin,41(2)) Expression profiling of candidate embryotrophic genes of buffalo oviduct during different stages of oestrous cycle (Buffalo Bulletin,41(2)) Fatty acid profile of Murrah buffalo milk fat (Buffalo Bulletin,41(1)) Dystocia due to Dicephalic dipus dibrachius monster in a Murrah buffalo (Buffalo Bulletin,41(3)) Dystocia due to bull dog calf in a Murrah buffalo heifer (Buffalo Bulletin,41(1)) Constraints of buffalo farming in Kallakurichi district of Tamil Nadu, India (Buffalo Bulletin,41(3)) Association of Melatonin receptor 1A (MTNR1A) gene polymorphism with seasonal suppression of fertility in buffaloes (Buffalo Bulletin,41(4)) Eigenvector selection indices for improving milk yield and persistency in Egyptian buffalo (Buffalo Bulletin,41(3)) Quality evaluation and safety assessment of buffalo milk collected from Mathura city (Buffalo Bulletin,41(3))
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