สืบค้นงานวิจัย
Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins
Nabu S. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins
ผู้แต่ง / หัวหน้าโครงการ (EN): Nabu S.
บทคัดย่อ (EN): Neisseria gonorrhoeae strains displaying reduced susceptibility and resistance to extended-spectrum cephalosporins (ESCs) are major public health concerns. Although resistance mechanisms of ESCs have extensively been studied, the proteome-wide investigation on the biological response to the antibiotic stress is still limited. Herein, a proteomics approach based on two-dimensional gel electrophoresis and MALDI-TOF/TOF-MS analysis was applied to investigate the global protein expression under ESC stresses of ESC-susceptible and ESCreduced susceptible N. gonorrhoeae strains. Upon exposure to ceftriaxone, 14 and 21 proteins of ESCsusceptible and ESC-reduced susceptible strains, respectively, were shown to be differentially expressed. In the meanwhile, differential expressions of 13 and 17 proteins were detected under cefixime stress for ESCsusceptible and ESC-reduced susceptible strains, respectively. ESC antibiotics have been proven to trigger the expression of several proteins implicated in a variety of biological functions including transport system, energy metabolism, stress response and pathogenic virulence factors. Interestingly, macrophage infectivity potentiators (Ng-MIP) showed increased expression for ESC-reduced susceptible strain under ESC stress. The altered expression of Ng-MIP was found to be a unique response to ESC stresses. Our finding proposes a broad view on proteomic changes in N. gonorrhoeae in response to ESC antibiotics that provides further insights into the gonococcal antimicrobial resistance and physiological adaptation mechanism. © 2017, Leibniz Research Centre for Working Environment and Human Factors. All rights reserved.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85038413281&doi=10.17179%2fexcli2017-832&partnerID=40&md5=c247945c84676908bd2038ea9c0f318e
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): two dimensional gel electrophoresis
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

Nabu S.. "Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins". ไม่ระบุหน่วยงาน. ม.ป.ป.

Nabu S.. "Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



TARR Wordcloud:
Comparative proteomics analysis of Neisseria gonorrhoeae strains in response to extended-spectrum cephalosporins
Nabu S.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Repositioning of 8-hydroxyquinoline derivatives as a new promising candidate for combating multidrug resistant Neisseria gonorrhoeae Phylogenetic analysis in various chicken strains inferred from mtDNA D-loop information Insights of Hevea Latex Serum Proteins Using Shotgun Proteomics Analysis Comparative HPLC analysis of phenolic compounds in the roots of Acanthopanax trifoliatus and acanthopanaxsenticosus Analysis of β-tubulin Genes of Corynespora cassiicola Strains Resistant to Carbendazim in China Comparative proteomic analysis of Chlamydomonas reinhardtii control and a salinity-tolerant strain revealed a differential protein expression pattern Metal complexation by histidine-rich peptides confers protective roles against cadmium stress in Escherichia coli as revealed by proteomics analysis Competitive crops for rubber plantations: A comparative financial analysis under Sri Lankan conditions Antimicrobial resistance, extended-spectrum b-Lactamase productivity, and class 1 integrons in Escherichia coli from healthy swine Comparative proteomics and protein profile related to phenolic compounds and antioxidant activity in germinated Oryza sativa ‘KDML105’ and Thai brown rice ‘Mali Daeng’ for better nutritional value
คัดลอก URL
กระทู้ของฉัน
ผลการสืบค้นทั้งหมด โพสต์     เรียงลำดับจาก
พัฒนาระบบโดยศูนย์ความรู้เฉพาะด้านวิศวกรรมความรู้และวิศวกรรมภาษาDeveloped by Center of Excellence for Unified Knowledge and Language Engineering
สนับสนุนโดยสำนักงานพัฒนาการวิจัยการเกษตร (องค์การมหาชน)Supported by the Agricultural Research Development Agency (Public Organization)
แบบสำรวจความพึงพอใจQuestionair