สืบค้นงานวิจัย
Anti-fibrotic and anti-inflammatory effects of parboiled germinated brown rice (Oryza sativa ‘KDML 105’) in rats with induced liver fibrosis
Wunjuntuk K. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Anti-fibrotic and anti-inflammatory effects of parboiled germinated brown rice (Oryza sativa ‘KDML 105’) in rats with induced liver fibrosis
ผู้แต่ง / หัวหน้าโครงการ (EN): Wunjuntuk K.
บทคัดย่อ (EN): Parboiled germinated brown rice (PGBR) is produced by steaming germinated paddy rice of Khao Dawk Mali 105 Thai rice variety. We conducted the study to determine the anti-fibrotic and anti-inflammatory effects of PGBR in rats induced by carbon tetrachloride (CCl 4 ). Male Sprague–Dawley rats were randomly divided into five groups: (1) control group, (2) CCl 4 group, (3) white rice (WR)+CCl 4 group, (4) brown rice (BR)+CCl 4 group, and (5) PGBR+CCl 4 group. All rats except control group were orally administrated with CCl 4 twice a week for 8 weeks. Rats in PGBR+CCl 4 group showed the hepatoprotective effects by significantly decreasing the markers of liver inflammation (TNF-α, IL-6 and IL-1β), fibrosis (TGF-β1, PDGF), and hydroxyproline content, as well as the score of necro-inflammation and fibrosis. In addition, PGBR suppressed the expression level of α-smooth muscle actin significantly as compared with CCl 4 group. These data suggested that regular consumption of PGBR could reduce liver inflammation and fibrosis. © 2016 Elsevier Ltd
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84982193696&doi=10.1016%2fj.jff.2016.08.009&partnerID=40&md5=031f5492482466b90591c4dc2a398e03
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Parboiled germinated brown rice
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Anti-fibrotic and anti-inflammatory effects of parboiled germinated brown rice (Oryza sativa ‘KDML 105’) in rats with induced liver fibrosis
Wunjuntuk K.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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