สืบค้นงานวิจัย
Effects of low bisphenol A concentration on protein expression profiles in an in vitro model of non-alcoholic fatty liver disease
Chienwichai P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Effects of low bisphenol A concentration on protein expression profiles in an in vitro model of non-alcoholic fatty liver disease
ผู้แต่ง / หัวหน้าโครงการ (EN): Chienwichai P.
บทคัดย่อ (EN): Bisphenol A (BPA) is an environmental toxicant that causes adverse effects to liver even at low concentrations. Non-alcoholic fatty liver disease (NAFLD) presents as significant accumulation of lipids in the liver, impairing detoxification processes. Nevertheless, little information is available regarding the susceptibility of NAFLD to BPA toxicity. Here, we compared the effects of low concentration BPA exposure on the protein profiles of normal and NAFLD cells. We established NAFLD model by treating HepG2 cells with fatty acids and subsequently treated with low BPA concentration. Protein expression profiles showed that four proteins from normal cells and nine proteins from NAFLD cells were dysregulated after BPA treatment. A pathway analysis revealed decreased expression of translation elongation factor proteins in NAFLD cells following BPA treatment and this down-regulation was confirmed by immunoblotting. Our findings suggest that BPA toxicity is more deleterious, especially to translation elongation, in NAFLD cells than normal cells. © 2018, The Korean Society of Toxicogenomics and Toxicoproteomics and Springer Science+Business Media B.V., part of Springer Nature.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039991590&doi=10.1007%2fs13273-018-0008-2&partnerID=40&md5=ebb3ba995830fd30a1923403a362068c
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Proteomics
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Chienwichai P.. "Effects of low bisphenol A concentration on protein expression profiles in an in vitro model of non-alcoholic fatty liver disease". ไม่ระบุหน่วยงาน. ม.ป.ป.

Chienwichai P.. "Effects of low bisphenol A concentration on protein expression profiles in an in vitro model of non-alcoholic fatty liver disease". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Effects of low bisphenol A concentration on protein expression profiles in an in vitro model of non-alcoholic fatty liver disease
Chienwichai P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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