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QuanFERON®-TB GOLD in-tUBE test for diagnosing latent tuberculosis infection among clinical-year Thai medical students
Benjawan Phetsuksiri - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): QuanFERON®-TB GOLD in-tUBE test for diagnosing latent tuberculosis infection among clinical-year Thai medical students
ผู้แต่ง / หัวหน้าโครงการ (EN): Benjawan Phetsuksiri
บทคัดย่อ (EN): Persons with latent tuberculosis infection (LTBI) are at-risk for developing subsequent active tuberculosis (TB). Screening for LTBI is important, especially in healthcare workers (HCWs) who have increased risk of acquiring TB. The new LTBI screening test, QuantiFERON®-TB Gold In-tube Test (QFT-IT) is now available in Thailand. However, data on the rate of positive test and factors associated with test positivity are limited among Thai medical students. We conducted a cross sectional study among clinical-year medical students (fourth to sixth year students) at Thammasat University, Thailand. All students who consented to participate in this study had the QFT-IT and a LTBI risk assessment during June 2014 as part of a health screening program. A total of 204 subjects were included in the program; their median age was 22 years (range: 20-34 years), 52% were female, 94% had a history of Bacillus Calmette-Guérin vaccination. Twenty subjects (10%) had a positive QFT-IT test and were presumed to have LTBI. The median interferon-γ (IFN-γ) level was 0.01 (range: 0-7.37 IU/ml). Independent factors associated with QFT-IT positivity were a history of direct TB contacts [adjusted odds ratio (aOR)=3.78; p=0.006), being a sixth year student (aOR=2.76; p=0.03) and having a history of working on a ward with active TB patients without having direct TB contacts (aOR=2.69; p=0.04]. The QFT-IT was useful in screening our study subjects and should be considered as a screening tool in this population due to the high incidence of QFT-IT positivity.
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ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=520
เผยแพร่โดย (EN): 1 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. 2 Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
คำสำคัญ (EN): QuantiFERON®-TB Gold In-tube Test; latent tuberculosis infection; clinical-year; medical students; Thailand
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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QuanFERON®-TB GOLD in-tUBE test for diagnosing latent tuberculosis infection among clinical-year Thai medical students
Benjawan Phetsuksiri
1 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand. 2 Division of Infectious Diseases, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.
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