สืบค้นงานวิจัย
Modulation of vaccine-induced CD4 T cell functional profiles by changes in components of HIV vaccine regimens in humans
Pissani F. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Modulation of vaccine-induced CD4 T cell functional profiles by changes in components of HIV vaccine regimens in humans
ผู้แต่ง / หัวหน้าโครงการ (EN): Pissani F.
บทคัดย่อ (EN): To date, six vaccine strategies have been evaluated in clinical trials for their efficacy at inducing protective immune responses against HIV infection. However, only the ALVAC-HIV/AIDSVAX B/E vaccine (RV144 trial) has demonstrated protection, albeit modestly (31%; P 0.03). One potential correlate of protection was a low-frequency HIV-specific CD4 T cell population with diverse functionality. Although CD4 T cells, particularly T follicular helper (Tfh) cells, are critical for effective antibody responses, most studies involving HIV vaccines have focused on humoral immunity or CD8 T cell effector responses, and little is known about the functionality and frequency of vaccine-induced CD4 T cells. We therefore assessed responses from several phase I/II clinical trials and compared them to responses to natural HIV-1 infection. We found that all vaccines induced a lower magnitude of HIV-specific CD4 T cell responses than that observed for chronic infection. Responses differed in functionality, with a CD40 ligand (CD40L)-dominated response and more Tfh cells after vaccination, whereas chronic HIV infection provoked tumor necrosis factor alpha (TNF-)-dominated responses. The vaccine delivery route further impacted CD4 T cells, showing a stronger Th1 polarization after dendritic cell delivery than after intramuscular vaccination. In prime/boost regimens, the choice of prime and boost influenced the functional profile of CD4 T cells to induce more or less polyfunctionality. In summary, vaccine-induced CD4 T cell responses differ remarkably between vaccination strategies, modes of delivery, and boosts and do not resemble those induced by chronic HIV infection. Understanding the functional profiles of CD4 T cells that best facilitate protective antibody responses will be critical if CD4 T cell responses are to be considered a clinical trial go/no-go criterion. Copyright © 2018 American Society for Microbiology. All Rights Reserved.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85056302811&doi=10.1128%2fJVI.01143-18&partnerID=40&md5=111109c6ac3e16d4b0bcda722b0fc9a3
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): vaccination
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Modulation of vaccine-induced CD4 T cell functional profiles by changes in components of HIV vaccine regimens in humans
Pissani F.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
HIV-1 vaccine-induced C1 and V2 Env-specific antibodies synergize for increased antiviral activities Characterization of HIV-1 gp120 antibody specificities induced in anogenital secretions of RV144 vaccine recipients after late boost immunizations CD8 and CD4 epitope predictions in RV144: No strong evidence of a T-cell driven sieve effect in HIV-1 Breakthrough sequences from trial participants Comprehensive Sieve Analysis of Breakthrough HIV-1 Sequences in the RV144 Vaccine Efficacy Trial Accuracy of clinical diagnosis of dengue episodes in the RV144 HIV vaccine efficacy trial in Thailand Monoclonal antibodies, derived from humans vaccinated with the RV144 HIV vaccine containing the HVEM binding domain of herpes simplex virus (HSV) glycoprotein D, neutralize HSV infection, mediate anti Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection Characterization of human CD8 T cell responses in dengue virus-infected patients from India Juvenile-specific cathepsin proteases in Fasciola spp.: their characteristics and vaccine efficacies Expansion of inefficient HIV-specific CD8 T cells during acute infection
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