สืบค้นงานวิจัย
Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen
Changrob S. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen
ผู้แต่ง / หัวหน้าโครงการ (EN): Changrob S.
บทคัดย่อ (EN): Rhoptry-associated membrane antigen (RAMA) is an abundant glycophosphatidylinositol (GPI)-anchored protein that is embedded within the lipid bilayer and is implicated in parasite invasion. Antibody responses against rhoptry proteins are produced by individuals living in a malaria-endemic area, suggesting the immunogenicity of Plasmodium vivax RAMA (PvRAMA) for induction of immune responses during P. vivax infection. To determine whether PvRAMA contributes to the acquisition of immunity to malaria and could be a rational candidate for a vaccine, the presence of memory T cells and the stability of the antibody response against PvRAMA were evaluated in P. vivax-exposed individuals. The immunogenicity of PvRAMA for the induction of T cell responses was evaluated by in vitro stimulation of peripheral blood mononuclear cells (PBMCs). High levels of interferon (IFN)-γ and interleukin (IL)-10 cytokines were detected in the culture supernatant of PBMCs, and the CD4+ T cells predominantly produced IL-10 cytokine. The levels of total anti-PvRAMA immunoglobulin G (IgG) antibody were significantly elevated, and these antibodies persisted over the 12 months of the study. Interestingly, IgG1, IgG2 and IgG3 were the major antibody subtypes in the response to PvRAMA. The frequency of IgG3 in specific to PvRAMA antigen maintained over 12 months. These data could explain the immunogenicity of PvRAMA antigen in induction of both cell-mediated and antibody-mediated immunity in natural P. vivax infection, in which IFN-γ helps antibody class switching toward the IgG1, IgG2 and IgG3 isotypes and IL-10 supports PvRAMA-specific antibody production. © 2016 Changrob et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84960396505&doi=10.1371%2fjournal.pone.0148723&partnerID=40&md5=3dcc15ac3428f2bde5b4ecbc2d6e8eb5
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Young Adult
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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การอ้างอิง

Changrob S.. "Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen". ไม่ระบุหน่วยงาน. ม.ป.ป.

Changrob S.. "Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Naturally-acquired immune response against Plasmodium vivax rhoptry-associated membrane antigen
Changrob S.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Insights into the naturally acquired immune response to Plasmodium vivax malaria A comparative study of natural immune responses against Plasmodium vivax C-terminal merozoite surface protein-1 (PvMSP-1) and apical membrane antigen-1 (PvAMA-1) in two endemic settings Haematological response in the treatment of naturally acquired ectoparasite infestations in rabbits Characterization of plasmodium vivax early transcribed membrane protein 11.2 and exported protein 1 Immune response to recombinant Burkholderia pseudomallei FliC Differential roles of an Anopheline midgut GPI-anchored protein in mediating Plasmodium falciparum and Plasmodium vivax ookinete invasion Immunogenicity and antigenicity of Plasmodium vivax merozoite surface protein 10 Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border The effects of feeding immunostimulant β-glucan on the immune response of Pangasianodon hypophthalmus Variable number of tandem repeats of 9 Plasmodium vivax genes among Southeast Asian isolates
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