คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Areerat Sa-Ngasang

เผยแพร่โดย

1 Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok; 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; 3 Molecular and Genetic Epidemiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan; and 4 Food and Drug Administration, Ministry of Public Heath, Nonthaburi, Thailand

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Wolbachia supergroups A and B in natural populations of medically important filth flies (Diptera : Muscidae, Calliphoridae, and Sarcophagidae) in Thailand Antibody response to Zika and Dengue virus among the Zika realtime PCR positive cases in Thailand, 2016 Prevalence of zoonotic Bartonella species among rodents and shrews in Thailand Draft Genome Sequence of a Clostridium botulinum Isolate from Thailand Harboring the Subtype bont/B8 Gene Circulation of HIV-1 Multiple Complexity Recombinant Forms Among Female Sex Workers Recently Infected with HIV-1 in Thailand Mangrove forests in Thailand Progress on Rubber Breeding of Thailand Molecular Characterization of Clostridium botulinum Isolates from Foodborne Outbreaks in Thailand, 2010

คัดลอก URL

ชื่อเรื่อง (EN):	Association of IL1B 31C/T and IL1RA Variable Number of an 86-bp Tandem Repeat With Dengue Shock Syndrome in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN):	Areerat Sa-Ngasang
บทคัดย่อ (EN):	Background. Dengue patients present a range of symptoms: dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS). It is not clear whether this variability is due to their genetic background. Here we tested polymorphisms of interleukin 1 beta (IL1B) and interleukin 1 receptor antagonist (IL1RA) genes for association with DSS in the Thai population. Methods. Polymorphisms of IL1B -31C/T (rs1143627) and IL1RA 86-base-pair tandem repeat were analyzed in 871 patients (DF = 384, DHF = 413, and DSS = 74). Results. IL1B -31C and IL1RA 2/4 genotype were associated with DSS (IL1B -31C: DSS vs DHF: P = .0061, odds ratio [OR, 95% confidence interval {CI}], 3.49 [1.36–8.95]; DSS vs DF: P = .027, OR [95% CI], 2.81 [1.12– 7.06]; IL1RA 2/4: DSS vs DHF: P = .017, OR [95% CI], 1.94 [1.12–3.40]; DSS vs DF: P = .024, OR [95% CI], 1.90 [1.07–3.4]). No difference was found between DF and DHF. Logistic regression analysis revealed that IL1B -31C and IL1RA 2/4 genotypes were each independently associated with DSS. Conclusions. Patients with IL1B -31C carrier, or IL1RA 2/4 genotype carry a risk for DSS, implying that IL1B may play a role in pathogenesis of DSS. Keywords. association; dengue shock syndrome; IL1B; IL1RA.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=443
เผยแพร่โดย (EN):	1 Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok; 2 National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand; 3 Molecular and Genetic Epidemiology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan; and 4 Food and Drug Administration, Ministry of Public Heath, Nonthaburi, Thailand
คำสำคัญ (EN):	Dengue Shock Syndrome in Thailand
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science