คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Satoshi Komoto

เผยแพร่โดย

1 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan, 2 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand, 3 Department of Virology II, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan, 4 Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan, 5 Genome and Transcriptome Analysis Center, Fujita Health University, Toyoake, Aichi, Japan, 6 Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan

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งานวิจัยที่แนะนำ Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Group B Streptococcal bacteremia burden and trends over time, 2007-15, Thailand Wolbachia supergroups A and B in natural populations of medically important filth flies (Diptera : Muscidae, Calliphoridae, and Sarcophagidae) in Thailand Whole Genomic Analysis of an Unusual Human G6P[14] Rotavirus Strain Isolated from a Child with Diarrhea in Thailand: Evidence for Bovine-To-Human Interspecies Transmission and Reassortment Events Full Genome Characterization of Novel DS-1-Like G8P[8] Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Re Detection, identification and characterization of enteric bacterial pathogens in a case-control study of acute diarrhea in Thailand High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand Full genomic analysis of a human G9P[23] rotavirus strain from a child with diarrhea in Thailand Prevalence of zoonotic Bartonella species among rodents and shrews in Thailand Characterization of an unusual DS-1-like G8P[8] rotavirus strain from Japan in 2017: evolution of emerging DS-1-like G8P[8] strains through reassortment

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ชื่อเรื่อง (EN):	Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN):	Satoshi Komoto
บทคัดย่อ (EN):	The emergence and rapid spread of unusual DS-1-like G1P[8] rotaviruses in Japan have been recently reported. During rotavirus surveillance in Thailand, three DS-1-like G1P[8] strains (RVA/Human-wt/THA/PCB-180/2013/G1P[8], RVA/Human-wt/THA/SKT-109/2013/ G1P[8], and RVA/Human-wt/THA/SSKT-41/2013/G1P[8]) were identified in stool specimens from hospitalized children with severe diarrhea. In this study, we sequenced and characterized the complete genomes of strains PCB-180, SKT-109, and SSKT-41. On whole genomic analysis, all three strains exhibited a unique genotype constellation including both genogroup 1 and 2 genes: G1-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. This novel genotype constellation is shared with Japanese DS-1-like G1P[8] strains. Phylogenetic analysis revealed that the G/P genes of strains PCB-180, SKT-109, and SSKT-41 appeared to have originated from human Wa-like G1P[8] strains. On the other hand, the non-G/P genes of the three strains were assumed to have originated from human DS-1-like strains. Thus, strains PCB-180, SKT-109, and SSKT-41 appeared to be derived through reassortment event(s) between Wa-like G1P[8] and DS-1-like human rotaviruses. Furthermore, strains PCB-180, SKT-109, and SSKT-41 were found to have the 11-segment genome almost indistinguishable from one another in their nucleotide sequences and phylogenetic lineages, indicating the derivation of the three strains from a common origin. Moreover, all the 11 genes of the three strains were closely related to those of Japanese DS-1-like G1P[8] strains. Therefore, DS-1-like G1P[8] strains that have emerged in Thailand and Japan were assumed to have originated from a recent common ancestor. To our knowledge, this is the first report on whole genome-based characterization of DS-1-like G1P[8] strains that have emerged in an area other than Japan. Our observations will provide important insights into the evolutionary dynamics of emerging DS-1-like G1P[8] rotaviruses.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=484
เผยแพร่โดย (EN):	1 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan, 2 Department of Medical Sciences, National Institute of Health, Nonthaburi, Thailand, 3 Department of Virology II, National Institute of Infectious Diseases, Musashi-Murayama, Tokyo, Japan, 4 Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi, Japan, 5 Genome and Transcriptome Analysis Center, Fujita Health University, Toyoake, Aichi, Japan, 6 Department of Microbiology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
คำสำคัญ (EN):	Children with Diarrhea in Thailand
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science