คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Tacharoenmuang

เผยแพร่โดย

1 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand. 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. 3 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. 4 Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ Reassortment of Human and Animal Rotavirus Gene Segments in Emerging DS-1- Like G1P[8] Rotavirus Strains Full genome characterization of novel DS-1-like G9P[8] rotavirus strains that have emerged in Thailand Whole Genomic Analysis of an Unusual Human G6P[14] Rotavirus Strain Isolated from a Child with Diarrhea in Thailand: Evidence for Bovine-To-Human Interspecies Transmission and Reassortment Events Emergence and Characterization of Unusual DS-1-Like G1P[8] Rotavirus Strains in Children with Diarrhea in Thailand Predominant Prevalence of Human Rotaviruses With the G1P[8] and G8P[8] Genotypes With a Short RNA Profile in 2013 and 2014 in Sukhothai and Phetchaboon Provinces, Thailand Predominant Prevalence of Human Rotaviruses With the G1P[8] and G8P[8] Genotypes With a Short RNA Profile in 2013 and 2014 in Sukhothai and Phetchaboon Provinces, Thailand Characterization of an unusual DS-1-like G8P[8] rotavirus strain from Japan in 2017: evolution of emerging DS-1-like G8P[8] strains through reassortment 10 สุดยอดแนวโน้มเทคโนโลยีเชิงกลยุทธ์สำหรับปี 2020 โดย Gartner The series EP. 4 : Human augmentation Mushroom Poisoning in Thailand: Incidence and Intoxication to Human Health Prevalence and Genetic Heterogeneity of Bartonella Strains Isolated from Rodents and Shrews from 9 Provinces in Thailand

คัดลอก URL

ชื่อเรื่อง (EN):	Full Genome Characterization of Novel DS-1-Like G8P[8] Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Reassortant Strains
ผู้แต่ง / หัวหน้าโครงการ (EN):	Tacharoenmuang
บทคัดย่อ (EN):	The emergence and rapid spread of unusual DS-1-like intergenogroup reassortant rotavirus strains have been recently reported in Asia, Australia, and Europe. During rotavirus surveillance in Thailand in 2013-2014, novel DS-1-like intergenogroup reassortant strains having G8P[8] genotypes (i.e., strains KKL-17, PCB-79, PCB-84, PCB-85, PCB-103, SKT-107, SWL-12, NP-130, PCB-656, SKT-457, SSKT-269, and SSL-55) were identified in stool samples from hospitalized children with severe diarrhea. In this study, we determined and characterized the complete genomes of these 12 strains (seven strains, KKL-17, PCB-79, PCB-84, PCB-85, PCB-103, SKT-107, and SWL-12, found in 2013 (2013 strains), and five, NP-130, PCB-656, SKT-457, SSKT-269, and SSL-55, in 2014 (2014 strains)). On full genomic analysis, all 12 strains showed a unique genotype constellation comprising a mixture of genogroup 1 and 2 genes: G8-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. With the exception of the G genotype, the unique genotype constellation of the 12 strains (P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2) was found to be shared with DS-1-like intergenogroup reassortant strains. On phylogenetic analysis, six of the 11 genes of the 2013 strains (VP4, VP2, VP3, NSP1, NSP3, and NSP5) appeared to have originated from DS-1-like intergenogroup reassortant strains, while the remaining four (VP7, VP6, VP1, and NSP2) and one (NSP4) gene appeared to be of bovine and human origin, respectively. Thus, the 2013 strains appeared to be reassortant strains as to DS-1-like intergenogroup reassortant, bovine, bovine-like human, and/or human rotaviruses. On the other hand, five of the 11 genes of the 2014 strains (VP4, VP2, VP3, NSP1, and NSP3) appeared to have originated from DS-1-like intergenogroup reassortant strains, while three (VP7, VP1, and NSP2) and one (NSP4) were assumed to be of bovine and human origin, respectively. Notably, the remaining two genes, VP6 and NSP5, of the 2014 strains appeared to have originated from locally circulating DS-1-like G2P[4] human rotaviruses. Thus, the 2014 strains were assumed to be multiple reassortment strains as to DS-1-like intergenogroup reassortant, bovine, bovine-like human, human, and/or locally circulating DS-1-like G2P[4] human rotaviruses. Overall, the great genomic diversity among the DS-1-like intergenogroup reassortant strains seemed to have been generated through additional reassortment events involving animal and human strains. Moreover, all the 11 genes of three of the 2014 strains, NP-130, PCB-656, and SSL-55, were very closely related to those of Vietnamese DS-1-like G8P[8] strains that emerged in 2014-2015, indicating the derivation of these DS-1-like G8P[8] strains from a common ancestor. To our knowledge, this is the first report on full genome-based characterization of DS-1-like G8P[8] strains that have emerged in Thailand. Our observations will add to our growing understanding of the evolutionary patterns of emerging DS-1-like intergenogroup reassortant strains
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=506
เผยแพร่โดย (EN):	1 National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand. 2 Department of Virology and Parasitology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. 3 Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. 4 Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand.
คำสำคัญ (EN):	Human Rotavirus Gene
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science