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Blood-induced differential gene expression in Anopheles dirus evaluated using RNA sequencing
Mongkol W. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Blood-induced differential gene expression in Anopheles dirus evaluated using RNA sequencing
ผู้แต่ง / หัวหน้าโครงการ (EN): Mongkol W.
บทคัดย่อ (EN): Malaria parasites are transmitted through blood feeding by female Anopheline mosquitoes. Unveiling the blood-feeding process will improve understanding of vector biology. Anopheles dirus (Diptera: Culicidae) is one of the primary malaria vectors in the Greater Mekong Subregion, the epicentre of malaria drug resistance. In this study, differential gene expression between sugar- and blood-fed An. dirus was investigated by RNA sequencing (RNA-seq). A total of 589 transcripts were found to be upregulated and 703 transcripts downregulated as a result of blood feeding. Transcriptional differences were found in genes involved in blood digestion, peritrophic matrix formation, oogenesis and vitellogenesis. The expression levels of several genes were validated by quantitative reverse transcription polymerase chain reaction. The present results provide better understanding of An. dirus biology in relation to its blood feeding. © 2018 The Royal Entomological Society
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85055977950&doi=10.1111%2fmve.12310&partnerID=40&md5=8f305ba3b4096d0873e871c73dbca5b4
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Up-Regulation
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Blood-induced differential gene expression in Anopheles dirus evaluated using RNA sequencing
Mongkol W.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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