คลังข้อมูลการวิจัยการเกษตรไทย

ผู้แต่ง Supaporn Suparak

เผยแพร่โดย

1 National Institute of Health, Department of Medical Sciences, Tiwanond Road, Nonthaburi 11000 2 Retired Government Official 23/30 Phaholyothin 60, Khu Khot, Lam Luka, Pathum Thani 12130 3 Pink Park Village, Queen Sirikit Centre for Breast Cancer Foundation 47, Nong Chok, Bangkok 10530,Thailand

เผยแพร่เมื่อ ไม่ระบุวันที่เผยแพร่

หน่วยงาน ไม่ระบุหน่วยงาน

งานวิจัยที่แนะนำ In vitro generation of dendritic cell - breast cancer cell hybrids for induction of cellular immunity Epigenetic reprogramming in mammalian cell differentiation, transdifferentiation and dedifferentiation Differentiation-inducing effect of piperitenone oxide, a fragrant ingredient of spearmint (Mentha spicata), but not carvone and menthol, against human colon cancer cells Real time monitoring cell proliferation of SW620 colorectal cancer cell line following co-culture with PHA-stimulated lymphocytes and CD44 expression following cytotoxic and apoptotic induction Characterization of an abalone gonadotropin-releasing hormone and its effect on ovarian cell proliferation Cytokine-induced killer cells: A novel treatment for allergic airway inflammation Partial nitrification in entrapped-cell-based reactors with two different cell-to-matrix ratios: performance, microenvironment, and microbial community Intracellular bacteria interfere with dendritic cell functions: Role of the type I interferon pathway Identification of changes in dendritic cell subsets that correlate with disease severity in dengue infection Generation of porcine induced-pluripotent stem cells from Sertoli cells

คัดลอก URL

ชื่อเรื่อง (EN):	Notch-1 Signaling Mediated Dendritic cells - Induced Autologous NK Cell Proliferation and Cytotoxicity Activity to Cancer Cell
ผู้แต่ง / หัวหน้าโครงการ (EN):	Supaporn Suparak
บทคัดย่อ (EN):	Natural killer (NK) cells mediated immune responses via cytotoxic activity, or secreting cytokines. The interaction of NK cells with dendritic cells (DCs) contributes to NK cell-mediated anti-tumor or anti-microbial responses. However, the cellular and molecular mechanisms for controlling DC-mediated NK cell cytotoxicity interaction are largely unknown. Here, we showed an involvement of Notch-1 signaling interaction in augmenting NK cell cytotoxicity mediated by DCs. Stimulation of DCs from 6 healthy donors with lipopolysaccharide (LPS) could induce Notch-1 receptor and enhance NK cell proliferation (64.71±1.89%) and their cytotoxicity activity (42.18±1.04%) against K562 cells (human erythroleukemic cell line). DC-mediated NK cell cytotoxicity was suppressed by Notch-1 inhibitor, a γ-secretase inhibitor, (11.91±0.62%), as compared to the LPS treated-DCs (p < 0.05, paired t-test). These results suggested a possible mechanism of DCs mediated NK cell expansion and cytotoxicity regarding to Notch-1 receptor, at least in part. These findings provided an insight that the modulation of Notch-1 signaling could be a strategy to eradicate tumors or to suppress NK cell-mediated diseases.
บทคัดย่อ:	ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN):	en
เอกสารแนบ (EN):	http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=747
เผยแพร่โดย (EN):	1 National Institute of Health, Department of Medical Sciences, Tiwanond Road, Nonthaburi 11000 2 Retired Government Official 23/30 Phaholyothin 60, Khu Khot, Lam Luka, Pathum Thani 12130 3 Pink Park Village, Queen Sirikit Centre for Breast Cancer Foundation 47, Nong Chok, Bangkok 10530,Thailand
คำสำคัญ (EN):	Notch-1 ชำนาญ
เจ้าของลิขสิทธิ์ (EN):	National Institute of Health, Department of Medical Science