สืบค้นงานวิจัย
Comparative proteomic study of dog and human saliva
Sanguansermsri P. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Comparative proteomic study of dog and human saliva
ผู้แต่ง / หัวหน้าโครงการ (EN): Sanguansermsri P.
บทคัดย่อ (EN): Saliva contains many proteins that have an important role in biological process of the oral cavity and is closely associated with many diseases. Although the dog is a common companion animal, the composition of salivary proteome and its relationship with that of human are unclear. In this study, shotgun proteomics was used to compare the salivary proteomes of 7 Thai village dogs and 7 human subjects. Salivary proteomes revealed 2,532 differentially expressed proteins in dogs and humans, representing various functions including cellular component organization or biogenesis, cellular process, localization, biological regulation, response to stimulus, developmental process, multicellular organismal process, metabolic process, immune system process, apoptosis and biological adhesion. The oral proteomes of dogs and humans were appreciably different. Proteins related to apoptosis processes and biological adhesion were predominated in dog saliva. Drug-target network predictions by STITCH Version 5.0 showed that dog salivary proteins were found to have potential roles in tumorigenesis, anti-inflammation and antimicrobial processes. In addition, proteins related to regeneration and healing processes such as fibroblast growth factor and epidermal growth factor were also up-regulated in dogs. These findings provide new information on dog saliva composition and will be beneficial for the study of dog saliva in diseased and health conditions in the future. © 2018 Sanguansermsri et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85057751006&doi=10.1371%2fjournal.pone.0208317&partnerID=40&md5=e7eb2a97088bfabb3d1d113335caa11f
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Salivary Proteins and Peptides
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

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Sanguansermsri P.. "Comparative proteomic study of dog and human saliva". ไม่ระบุหน่วยงาน. ม.ป.ป.

Sanguansermsri P.. "Comparative proteomic study of dog and human saliva". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Comparative proteomic study of dog and human saliva
Sanguansermsri P.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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