สืบค้นงานวิจัย
Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure
Tieu H.-V. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure
ผู้แต่ง / หัวหน้าโครงการ (EN): Tieu H.-V.
บทคัดย่อ (EN): Data on the performance of interferon-gamma release assays (IGRAs), QuantiFERON TB Gold In-tube (QFNGIT) and T-Spot.TB, in diagnosing tuberculosis (TB) are limited in Southeast Asia. This study aims to compare the performances of the two IGRAs and TST in Thai children with recent TB exposure. Methods: This multicenter, prospective study enrolled children with recent exposure to active TB adults. Children were investigated for active TB. TST was performed and blood collected for T-Spot.TB and QFNGIT. Results: 158 children were enrolled (87% TB-exposed and 13% active TB, mean age 7.2 years). Only 3 children had HIV infection. 66.7% had TST≥10 mm, while 38.6% had TST≥15 mm. 32.5% had positive QFNGIT; 29.9% had positive T-Spot.TB. QFNGIT and T-Spot.TB positivity was higher among children with active TB compared with TB-exposed children. No indeterminate IGRA results were detected. No statistically significant differences between the performances of the IGRAs and TST at the two cut-offs with increasing TB exposure were detected. Concordance for positive IGRAs and TST ranged from 42-46% for TST≥10 mm and 62-67% for TST≥15 mm. On multivariable analyses, exposure to household primary/secondary caregiver with TB was associated with positive QFNGIT. Higher TB contact score and active TB were associated with positive T-Spot.TB. Conclusions: Both QFNGIT and T-Spot.TB performed well in our Thai pediatric study population. No differences in the performances between tests with increasing TB exposure were found. Due to accessibility and low cost, using TST may more ideal than IGRAs in diagnosing latent and active TB in healthy children in Thailand and other similar settings. © 2014 Tieu et al.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905978353&doi=10.1371%2fjournal.pone.0105003&partnerID=40&md5=cd6f7298abe65445185fbd085468e597
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Tuberculin Test
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Tieu H.-V.. "Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure". ไม่ระบุหน่วยงาน. ม.ป.ป.

Tieu H.-V.. "Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Comparing interferon-gamma release assays to tuberculin skin test in thai children with tuberculosis exposure
Tieu H.-V.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
Tuberculin skin test and QuantiFERON-TB Gold In-tube Test for latent tuberculosis in Thai HIV-infected adults Tuberculin skin test and QuantiFERON®-TB Gold In-tube Test for diagnosing latent tuberculosis infection among Thai healthcare workers T-SPOT.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers T-SPOT®.TB test and clinical risk scoring for diagnosis of latent tuberculosis infection among Thai healthcare workers. QuanFERON®-TB GOLD in-tUBE test for diagnosing latent tuberculosis infection among clinical-year Thai medical students T‑SPOT®.TB Test for Latent Tuberculosis infection Diagnosis and Treatment Guidance in Thai Health‑Care Professionals Detection of Mycobacterium tuberculosis and Its Rifampicin Resistance by Automated Nucleic Acid Amplification Test Rapid screening drug susceptibility test in tuberculosis using sandwich electrochemical immunosensor QuantiFERON-TB Gold In-Tube Test for Tuberculosis Prevention in HIV-Infected Patients QuantiFERON-TB Gold In-Tube test in active tuberculosis patients and healthy adults
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