สืบค้นงานวิจัย
HPTLC simultaneous quantification of triterpene acids for quality control of Plantago major L. and evaluation of their cytotoxic and antioxidant activities
Kartini - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): HPTLC simultaneous quantification of triterpene acids for quality control of Plantago major L. and evaluation of their cytotoxic and antioxidant activities
ผู้แต่ง / หัวหน้าโครงการ (EN): Kartini
บทคัดย่อ (EN): A validated high performance thin-layer chromatography (HPTLC) method was developed for simultaneous determination of ursolic acid (UA) and oleanolic acid (OA) contents in Plantago major which were collected from several plantation areas in Indonesia. The cytotoxic effect against two cancer cell lines, SiHa and Hep G2, and antioxidant activity were evaluated using the MTT and DPPH-radical scavenging assay, respectively. The test samples included various extracts of P. major from different plant parts using methanol and water as extracting solvents and pure compounds derived from this plant. The results showed that both plant parts and extracting solvents affected the chemical contents and their biological activities. The contents of UA and OA varied according to the organs and provenances of plant. The highest content of UA (0.22-0.48% dry weight) and OA (0.17-0.33% dry weight) were found in the methanol extract of seed. This extract also exhibited the highest cytotoxic activity (IC50 value: 174.42-246.38μg/ml), whereas the strongest free radical scavenging activity was obtained from the leaf methanol extract (IC50 value: 263.57μg/ml). The developed HPTLC method can be used for routine analysis and standardization of P. major crude drugs, extracts, and/or finished products using UA and OA as appropriate markers for anticancer products. © 2014 Elsevier B.V.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-84903850416&doi=10.1016%2fj.indcrop.2014.06.020&partnerID=40&md5=bf351bbb7e62f01259f5e90abb7a6656
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): terpene
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

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Kartini. "HPTLC simultaneous quantification of triterpene acids for quality control of Plantago major L. and evaluation of their cytotoxic and antioxidant activities". ไม่ระบุหน่วยงาน. ม.ป.ป.

Kartini. "HPTLC simultaneous quantification of triterpene acids for quality control of Plantago major L. and evaluation of their cytotoxic and antioxidant activities". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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HPTLC simultaneous quantification of triterpene acids for quality control of Plantago major L. and evaluation of their cytotoxic and antioxidant activities
Kartini
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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