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Optimal Discriminating Concentrations of Six Synthetic Pyrethroids for Monitoring Insecticide Susceptibility in Anopheles minimus (Diptera: Culicidae), a Primary Malaria Vector in Thailand
Thanispong - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Optimal Discriminating Concentrations of Six Synthetic Pyrethroids for Monitoring Insecticide Susceptibility in Anopheles minimus (Diptera: Culicidae), a Primary Malaria Vector in Thailand
ผู้แต่ง / หัวหน้าโครงการ (EN): Thanispong
บทคัดย่อ (EN): Malaria is a serious mosquito-borne disease transmitted to humans by Anopheles mosquitoes. Seven species of Anopheles are important malaria vectors in Thailand and all remain susceptible to pyrethroid insecticides, despite decades of use in public health mosquito control programs. However, for a more refined and accurate approach to temporal monitoring of susceptibility patterns to commonly used pyrethroids to control adult Anopheles mosquitoes, it is preferred to have specific concentrations for more discriminating testing. A laboratory strain of Anopheles minimus Theobald was used to establish baseline concentrations for susceptibility to six different synthetic pyrethroids—deltamethrin, permethrin, bifenthrin, cypermethrin, α-cypermethrin, and λ-cyhalothrin using the World Health Organization (WHO) adult bioassay system. Final discriminating concentrations of each active ingredient were determined based on doubling LC99 for each chemical to arrive at the following percent concentrations: deltamethrin (0.009%), permethrin (0.551%), bifenthrin (0.12%), cypermethrin (0.104%), α-cypermethrin (0.034%), and λ-cyhalothrin (0.019%). For permethrin, deltamethrin, α-cypermethrin, and λ-cyhalothrin, all revised percentages were lower than currently recommended discriminating concentrations by WHO. Using the newly derived concentrations, insecticide susceptibility tests were followed in a field population of An. minimus s.l. from Kanchanaburi Province. Deltamethrin, bifenthrin, and λ-cyhalothrin produced 100% kill, whereas permethrin, cypermethrin, and α-cypermethrin gave between 92.9 and 97.7% mortality, indicating lower sensitivity (tolerance). Routine monitoring of insecticide susceptibility in An. minimus wild populations throughout Thailand should continue to ensure that insecticides in use are effective to control this vector species.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): http://nih.dmsc.moph.go.th/research/showimgdetil.php?id=531
เผยแพร่โดย (EN): 1 Department of Disease Control, Bureau of Vector-Borne Diseases, Ministry of Public Health, Nonthaburi 11000, Thailand. 2 Department of Medical Sciences, National Institute of Health, Ministry of Public Health, Nonthaburi 11000, Thailand. 3 Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand. 4 Department of Pest Management, Faculty of Natural Resources, Prince of Songkla University, Songkhla 90112, Thailand. 5 Public Health and Malaria Control Department, PT. Freeport Indonesia, International SOS, Kuala Kencana, Papua 99920, Indonesia.
คำสำคัญ (EN): Anopheles minimus; insecticide discriminating concentrations; pyrethroid; adult contact bioassay
เจ้าของลิขสิทธิ์ (EN): National Institute of Health, Department of Medical Science
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Optimal Discriminating Concentrations of Six Synthetic Pyrethroids for Monitoring Insecticide Susceptibility in Anopheles minimus (Diptera: Culicidae), a Primary Malaria Vector in Thailand
Thanispong
1 Department of Disease Control, Bureau of Vector-Borne Diseases, Ministry of Public Health, Nonthaburi 11000, Thailand. 2 Department of Medical Sciences, National Institute of Health, Ministry of Public Health, Nonthaburi 11000, Thailand. 3 Department of Entomology, Faculty of Agriculture, Kasetsart University, Bangkok 10900, Thailand. 4 Department of Pest Management, Faculty of Natural Resources, Prince of Songkla University, Songkhla 90112, Thailand. 5 Public Health and Malaria Control Department, PT. Freeport Indonesia, International SOS, Kuala Kencana, Papua 99920, Indonesia.
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