สืบค้นงานวิจัย
Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling
DeBerg H.A. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling
ผู้แต่ง / หัวหน้าโครงการ (EN): DeBerg H.A.
บทคัดย่อ (EN): Globally, diarrheal diseases are a leading cause of death in children under five and disproportionately affect children in developing countries. Children who contract diarrheal diseases are rarely screened to identify the etiologic agent due to time and cost considerations associated with pathogen-specific screening and hence pathogen-directed therapy is uncommon. The development of biomarkers to rapidly identify underlying pathogens could improve treatment options and clinical outcomes in childhood diarrheal diseases. Here, we perform RNA sequencing on blood samples collected from children evaluated in an emergency room setting with diarrheal disease where the pathogen(s) present are known. We determine host response gene signatures specific to Salmonella, Shigella and rotavirus, but not E. coli, infections that distinguish them from each other and from healthy controls. Specifically, we observed differential expression of genes related to chemokine receptors or inflammasome signaling in Shigella cases, such as CCR3, CXCR8, and NLRC4, and interferon response genes, such as IFI44 and OASL, in rotavirus cases. Our findings add insight into the host peripheral immune response to these pathogens, and suggest strategies and limitations for the use host response transcript signatures for diagnosing the etiologic agent of childhood diarrheal diseases. © 2018 DeBerg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85041130882&doi=10.1371%2fjournal.pone.0192082&partnerID=40&md5=d712f2ee9f8debcd4a5fd6083cad1bdb
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Shigella
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
หากไม่พบเอกสารฉบับเต็ม (Full Text) โปรดติดต่อหน่วยงานเจ้าของข้อมูล

การอ้างอิง

DeBerg H.A.. "Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling". ไม่ระบุหน่วยงาน. ม.ป.ป.

DeBerg H.A.. "Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Shared and organism-specific host responses to childhood diarrheal diseases revealed by whole blood transcript profiling
DeBerg H.A.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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