สืบค้นงานวิจัย
Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteremia
Sirijatuphat R. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteremia
ผู้แต่ง / หัวหน้าโครงการ (EN): Sirijatuphat R.
บทคัดย่อ (EN): The global antimicrobial resistance surveillance system (GLASS) was launched by the World Health Organization (WHO) in 2015. GLASS is a surveillance system for clinical specimens that are sent to microbiology laboratory for clinical purposes. The unique feature of GLASS is that clinical data is combined with microbiological data, and deduplication of the microbiological results is performed. The objective of the study was to determine feasibility and benefit of GLASS for surveillance of blood culture specimens. GLASS was implemented at Siriraj Hospital in Bangkok, Thailand using a locally developed web application program (app) to transfer blood culture specimen data, and to enter clinical data of patients with positive blood culture by infection control nurses and physicians via the app installed in their smart phones. The rate of positive blood culture specimens with true infection was 15.2%. Escherichia coli was the most common cause of bacteremia. Secondary bacteremia, primary bacteremia, and central line-associated blood stream infection was observed in 61.8%, 30.6%, and 12.6% of cases, respectively. Sepsis was observed in 56.9% of patients. E.coli was significantly more common in community-acquired bacteremia, whereas Klebsiella pneumoniae, Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and Acinetobacter baumannii were significantly more common in hospital-acquired bacteremia. Hospital-acquired isolates of E.coli, K.pneumoniae, A.baumannii, P.aeruginosa, S.aureus and Enterococcus faecium were more resistant to antibiotics than community-acquired isolates. In-hospital mortality was significantly higher in patients with antibiotic-resistant bacteremia than in patients with antibiotic non-resistant bacteremia (40.5% vs. 28.5%, p<0.001). The patients with antibiotic-resistant bacteremia consumed more resources than those with antibiotic non-resistant bacteremia. Blood culture results combined with patient clinical data were shown to have more benefit for surveillance of antimicrobial resistance, and to be more applicable for developing local antibiotic treatment guidelines for patients suspected of having bacteremia. However, GLASS consumed more time and more resources than the conventional laboratory-based surveillance system. © 2018 Sirijatuphat et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85040000842&doi=10.1371%2fjournal.pone.0190132&partnerID=40&md5=81a951c18a2603da12adf4142a3059ea
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): Internet
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Sirijatuphat R.. "Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteremia". ไม่ระบุหน่วยงาน. ม.ป.ป.

Sirijatuphat R.. "Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteremia". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Implementation of global antimicrobial resistance surveillance system (GLASS) in patients with bacteremia
Sirijatuphat R.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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