สืบค้นงานวิจัย
Hepatic autotaxin overexpression in infants with biliary atresia
Udomsinprasert W. - ไม่ระบุหน่วยงาน
ชื่อเรื่อง (EN): Hepatic autotaxin overexpression in infants with biliary atresia
ผู้แต่ง / หัวหน้าโครงการ (EN): Udomsinprasert W.
บทคัดย่อ (EN): . Autotaxin (ATX) is a secreted glycoprotein that is involved in the development of hepatic fibrogenesis via the enzymatic production of lysophosphatidic acid. The aim of this study was to investigate hepatic expression of ATX in biliary atresia (BA) compared with non-BA liver controls and to examine the association betweenATX expression and clinical outcome in BA. Methods. Liver specimens from BA infants (nD20) were compared with samples from infants who underwent liver biopsy for reasons other than BA (nD14) and served as controls. RelativemRNAand protein expression ofATXwere quantified using real-time polymerase chain reaction (PCR) and immunohistochemistry. Masson's Trichrome staining was performed to determine the degree of liver fibrosis. Results. Quantitative real-time PCR demonstrated overexpression of ATX mRNA in BA livers. In immunohistochemical evaluation, ATX was positively stained on the hepatic parenchyma and the biliary epithelium in BA patients, as compared to non-BA controls. The immunostaining score of ATX in BA livers was also significantly higher than that observed in non-BA livers (P < 0:001). Subgroup analysis revealed that ATX expression in the patients with poor outcomes was significantly greater than in those with good outcomes (P D0:03). Additionally, there was a positive correlation between hepatic ATX expression and Metavir fibrosis stage in BA livers (r D0:79, P < 0:001). Discussion. This study found thatmRNAand protein expression ofATXwere increased in BA livers. High hepatic ATX expression at the time of Kasai operation was associated with liver fibrosis and outcome in BA, suggesting that ATX may serve a role as a promising biomarker of the prognosis in biliary atresia. © 2018 Udomsinprasert et al.
บทคัดย่อ: ไม่พบข้อมูลจากหน่วยงานต้นทาง
ภาษา (EN): en
เอกสารแนบ (EN): https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050640287&doi=10.7717%2fpeerj.5224&partnerID=40&md5=c10f76a672b574dd4e305c11695dc830
เผยแพร่โดย (EN): มหาวิทยาลัยมหิดล
คำสำคัญ (EN): very elderly
เจ้าของลิขสิทธิ์ (EN): มหาวิทยาลัยมหิดล
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Udomsinprasert W.. "Hepatic autotaxin overexpression in infants with biliary atresia". ไม่ระบุหน่วยงาน. ม.ป.ป.

Udomsinprasert W.. "Hepatic autotaxin overexpression in infants with biliary atresia". ไม่ระบุหน่วยงาน. ม.ป.ป.. Print.



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Hepatic autotaxin overexpression in infants with biliary atresia
Udomsinprasert W.
มหาวิทยาลัยมหิดล
ไม่ระบุวันที่เผยแพร่
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